Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty

Shady T. Awwad, Walid Haddad, Ming X. Wang, Dipak Parmar, Darrel Conger, Harrison D Cavanagh

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background. An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin-polymixin B - dexamethasone ophthalmic ointment. Methods. A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed. Results. Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea. Conclusions. Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalEye and Contact Lens
Volume30
Issue number3
DOIs
StatePublished - Jul 2004

Fingerprint

Penetrating Keratoplasty
Fluoroquinolones
Confocal Microscopy
Cornea
Framycetin
Corneal Epithelium
Ophthalmic Solutions
Ciprofloxacin
Ointments
Dexamethasone
Physical Examination
Suspensions
History
gatifloxacin

Keywords

  • Confocal microscopy
  • Cornea
  • Crystals
  • Gatifloxacin
  • Penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty. / Awwad, Shady T.; Haddad, Walid; Wang, Ming X.; Parmar, Dipak; Conger, Darrel; Cavanagh, Harrison D.

In: Eye and Contact Lens, Vol. 30, No. 3, 07.2004, p. 169-172.

Research output: Contribution to journalArticle

Awwad, Shady T. ; Haddad, Walid ; Wang, Ming X. ; Parmar, Dipak ; Conger, Darrel ; Cavanagh, Harrison D. / Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty. In: Eye and Contact Lens. 2004 ; Vol. 30, No. 3. pp. 169-172.
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AU - Conger, Darrel

AU - Cavanagh, Harrison D

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N2 - Background. An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin-polymixin B - dexamethasone ophthalmic ointment. Methods. A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed. Results. Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea. Conclusions. Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.

AB - Background. An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin-polymixin B - dexamethasone ophthalmic ointment. Methods. A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed. Results. Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea. Conclusions. Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.

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KW - Penetrating keratoplasty

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