TY - JOUR
T1 - Coronary angiographic scoring systems
T2 - An evaluation of their equivalence and validity
AU - Neeland, Ian J.
AU - Patel, Riyaz S.
AU - Eshtehardi, Parham
AU - Dhawan, Saurabh
AU - McDaniel, Michael C.
AU - Rab, S. Tanveer
AU - Vaccarino, Viola
AU - Zafari, A. Maziar
AU - Samady, Habib
AU - Quyyumi, Arshed A.
N1 - Funding Information:
Dr. Samady reports a research grant by Volcano Corporation.
Funding Information:
This work was supported by the Robert W. Woodruff Health Sciences Center Fund and the Emory Heart and Vascular Center Fund (both in Atlanta, GA), by a research grant to Dr. Samady from Volcano Corporation, and supported in part by NIH Grant UL1 RR025008 from the Clinical and Translational Science Award program and NIH R01HL089650-02 . The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the article, and its final contents.
PY - 2012/10
Y1 - 2012/10
N2 - Background: Multiple scoring systems have been devised to quantify angiographic coronary artery disease (CAD) burden, but it is unclear how these scores relate to each other and which scores are most accurate. The aim of this study was to compare coronary angiographic scoring systems (1) with each other and (2) with intravascular ultrasound (IVUS)-derived plaque burden in a population undergoing angiographic evaluation for CAD. Methods: Coronary angiographic data from 3600 patients were scored using 10 commonly used angiographic scoring systems and interscore correlations were calculated. In a subset of 50 patients, plaque burden and plaque area in the left anterior descending coronary artery were quantified using IVUS and correlated with angiographic scores. Results: All angiographic scores correlated with each other (range for Spearman coefficient [ρ] 0.79-0.98, P <.0001); the 2 most widely used scores, Gensini and CASS-70, had a ρ = 0.90 (P <.0001). All scores correlated significantly with average plaque burden and plaque area by IVUS (range ρ 0.56-0.78, P <.0001 and 0.43-0.62, P <.01, respectively). The CASS-50 score had the strongest correlation (ρ 0.78 and 0.62, P <.0001) and the Duke Jeopardy score the weakest correlation (ρ 0.56 and 0.43, P <.01) with plaque burden and area, respectively. Conclusions: Angiographic scoring systems are strongly correlated with each other and with atherosclerotic plaque burden. Scoring systems therefore appear to be a valid estimate of CAD plaque burden.
AB - Background: Multiple scoring systems have been devised to quantify angiographic coronary artery disease (CAD) burden, but it is unclear how these scores relate to each other and which scores are most accurate. The aim of this study was to compare coronary angiographic scoring systems (1) with each other and (2) with intravascular ultrasound (IVUS)-derived plaque burden in a population undergoing angiographic evaluation for CAD. Methods: Coronary angiographic data from 3600 patients were scored using 10 commonly used angiographic scoring systems and interscore correlations were calculated. In a subset of 50 patients, plaque burden and plaque area in the left anterior descending coronary artery were quantified using IVUS and correlated with angiographic scores. Results: All angiographic scores correlated with each other (range for Spearman coefficient [ρ] 0.79-0.98, P <.0001); the 2 most widely used scores, Gensini and CASS-70, had a ρ = 0.90 (P <.0001). All scores correlated significantly with average plaque burden and plaque area by IVUS (range ρ 0.56-0.78, P <.0001 and 0.43-0.62, P <.01, respectively). The CASS-50 score had the strongest correlation (ρ 0.78 and 0.62, P <.0001) and the Duke Jeopardy score the weakest correlation (ρ 0.56 and 0.43, P <.01) with plaque burden and area, respectively. Conclusions: Angiographic scoring systems are strongly correlated with each other and with atherosclerotic plaque burden. Scoring systems therefore appear to be a valid estimate of CAD plaque burden.
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U2 - 10.1016/j.ahj.2012.07.007
DO - 10.1016/j.ahj.2012.07.007
M3 - Article
C2 - 23067913
AN - SCOPUS:84867565966
SN - 0002-8703
VL - 164
SP - 547-552.e1
JO - American heart journal
JF - American heart journal
IS - 4
ER -