Coronary artery disease is highly prevalent among patients with premature peripheral vascular disease

R. J. Valentine, P. A. Grayburn, E. J. Eichhorn, S. I. Myers, G. P. Clagett

Research output: Contribution to journalArticle

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Abstract

Purpose: This study was designed to document the prevalence of coronary artery disease (CAD) and associated cardiac complications among patients with symptoms of premature peripheral vascular disease. Methods: We studied the peripheral and coronary arterial circulations of 59 consecutive male military veterans diagnosed with premature peripheral vascular disease (age of onset ≤ 45 years) affecting the lower extremity. Patients who had not previously undergone coronary angiography underwent exercise stress testing. Patients unable to perform exercise testing and those with abnormal exercise test results underwent coronary angiography. Results: There was no evidence of CAD in 16 patients (29%) on the basis of normal exercise test results (n = 12) or normal coronary angiography results (n = 4). Forty-three patients (71%) had significant (≥ 50% lesion) CAD by coronary catheterization. Cardiac complications were frequent among the 43 patients. Eleven (65%) of the 17 patients with single-vessel CAD had previously documented myocardial infarctions, as did three (75%) of the four patients with two-vessel CAD and 18 (82%) of the 22 patients with three vessel or greater CAD. Three (18%) patients with one-vessel CAD had undergone coronary artery bypass grafting or percutaneous transluminal coronary angioplasty for symptoms as had one patient (25%) with two-vessel CAD and 19 patients (86%) with three-vessel or greater CAD. Five patients died during the study period, four of myocardial infarction and one of stroke. Conclusions: Premature peripheral atherosclerosis is associated with a high prevalence of CAD. Detection of CAD is important in this group, because cardiac complications are frequent.

Original languageEnglish (US)
Pages (from-to)668-674
Number of pages7
JournalJournal of Vascular Surgery
Volume19
Issue number4
StatePublished - 1994

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Peripheral Vascular Diseases
Coronary Artery Disease
Coronary Angiography
Exercise Test
Myocardial Infarction
Exercise
Coronary Circulation
Coronary Balloon Angioplasty
Veterans
Age of Onset
Coronary Artery Bypass
Catheterization
Lower Extremity
Atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Valentine, R. J., Grayburn, P. A., Eichhorn, E. J., Myers, S. I., & Clagett, G. P. (1994). Coronary artery disease is highly prevalent among patients with premature peripheral vascular disease. Journal of Vascular Surgery, 19(4), 668-674.

Coronary artery disease is highly prevalent among patients with premature peripheral vascular disease. / Valentine, R. J.; Grayburn, P. A.; Eichhorn, E. J.; Myers, S. I.; Clagett, G. P.

In: Journal of Vascular Surgery, Vol. 19, No. 4, 1994, p. 668-674.

Research output: Contribution to journalArticle

Valentine, RJ, Grayburn, PA, Eichhorn, EJ, Myers, SI & Clagett, GP 1994, 'Coronary artery disease is highly prevalent among patients with premature peripheral vascular disease', Journal of Vascular Surgery, vol. 19, no. 4, pp. 668-674.
Valentine, R. J. ; Grayburn, P. A. ; Eichhorn, E. J. ; Myers, S. I. ; Clagett, G. P. / Coronary artery disease is highly prevalent among patients with premature peripheral vascular disease. In: Journal of Vascular Surgery. 1994 ; Vol. 19, No. 4. pp. 668-674.
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