Coronary atherosclerosis imaging by coronary CT angiography: Current status, correlation with intravascular interrogation and meta-analysis

Szilard Voros, Sarah Rinehart, Zhen Qian, Parag Joshi, Gustavo Vazquez, Collin Fischer, Pallavi Belur, Edward Hulten, Todd C. Villines

Research output: Contribution to journalReview article

211 Scopus citations

Abstract

Coronary computed tomography angiography (CTA) allows coronary artery visualization and the detection of coronary stenoses. In addition; it has been suggested as a novel, noninvasive modality for coronary atherosclerotic plaque detection, characterization, and quantification. Emerging data show that coronary CTA-based semiquantitative plaque characterization and quantification are sufficiently reproducible for clinical purposes, and fully quantitative approaches may be appropriate for use in clinical trials. Furthermore, several lines of investigation have validated plaque imaging by coronary CTA against other imaging modalities such as intravascular ultrasound/"virtual histology" and optical coherence tomography, and there are emerging data using biochemical modalities such as near-infrared spectroscopy. Finally, clinical validation in patients with acute coronary syndrome and in the outpatient setting has shown incremental value of CTA-based plaque characterization for the prediction of major cardiovascular events. With recent developments in image acquisition and reconstruction technologies, coronary CTA can be performed with relatively low radiation exposure. With further technological innovation and clinical research, coronary CTA may become an important tool in the quest to identify vulnerable plaques and the at-risk patient.

Original languageEnglish (US)
Pages (from-to)537-548
Number of pages12
JournalJACC: Cardiovascular Imaging
Volume4
Issue number5
DOIs
StatePublished - May 1 2011

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Keywords

  • atherosclerosis
  • coronary computed tomography angiography
  • intravascular ultrasound
  • meta-analysis
  • near-infrared spectroscopy
  • plaque imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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