Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease

Gerald F. Greil, Achim Seeger, Stephan Miller, Claus D. Claussen, Michael Hofbeck, René M. Botnar, Ludger Sieverding

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Background: In patients with Kawasaki disease (KD) serial evaluation of the distribution and size of coronary artery aneurysms (CAA) is necessary for risk stratification and therapeutic management. Objective: To apply whole-heart coronary MR angiography (CMRA) and black-blood coronary vessel wall imaging in children with KD. Materialsand methods: Six children (mean age 4.6 years, range 2.5-7.8 years) with KD underwent CMRA using a free-breathing, T2-prepared, three-dimensional steady-state free-precession (3D-SSFP), whole-heart approach with navigator gating and tracking. Vessel walls were imaged with an ECG-triggered and navigator-gated double inversion recovery (DIR) black-blood segmented turbo spin-echo sequence. Results: There was complete agreement between CMRA and conventional angiography (n=6) in the detection of CAA (n=15). Excellent agreement was found between the two techniques in determining the maximal diameter (mean difference 0.2±0.7 mm), length (mean difference 0.1±0.8 mm) and distance from the ostium (mean difference -0.8±2.1 mm) of the CAAs. In all subjects with a CAA, abnormally thickened vessel walls were found (2.5±0.5 mm). Conclusions: CMRA accurately defines CAA in free-breathing sedated children with KD using the whole-heart approach and detects abnormally thickened vessel walls. This technique may reduce the need for serial X-ray coronary angiography, and improve risk stratification and monitoring of therapy.

Original languageEnglish (US)
Pages (from-to)666-673
Number of pages8
JournalPediatric Radiology
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2007

Keywords

  • Children
  • Coronary MRA
  • Coronary artery aneurysm
  • Kawasaki disease
  • MRI
  • Vessel wall imaging

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

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    Greil, G. F., Seeger, A., Miller, S., Claussen, C. D., Hofbeck, M., Botnar, R. M., & Sieverding, L. (2007). Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease. Pediatric Radiology, 37(7), 666-673. https://doi.org/10.1007/s00247-007-0498-x