Coronary MR angiography at 3T: fat suppression versus water-fat separation

Maryam Nezafat, Markus Henningsson, David P. Ripley, Nathalie Dedieu, Gerald Greil, John P. Greenwood, Peter Börnert, Sven Plein, René M. Botnar

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

Objectives: To compare Dixon water-fat suppression with spectral pre-saturation with inversion recovery (SPIR) at 3T for coronary magnetic resonance angiography (MRA) and to demonstrate the feasibility of fat suppressed coronary MRA at 3T without administration of a contrast agent. Materials and methods: Coronary MRA with Dixon water-fat separation or with SPIR fat suppression was compared on a 3T scanner equipped with a 32-channel cardiac receiver coil. Eight healthy volunteers were examined. Contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), right coronary artery (RCA), and left anterior descending (LAD) coronary artery sharpness and length were measured and statistically compared. Two experienced cardiologists graded the visual image quality of reformatted Dixon and SPIR images (1: poor quality to 5: excellent quality). Results: Coronary MRA images in healthy volunteers showed improved contrast with the Dixon technique compared to SPIR (CNR blood-fat: Dixon = 14.9 ± 2.9 and SPIR = 13.9 ± 2.1; p = 0.08, CNR blood-myocardium: Dixon = 10.2 ± 2.7 and SPIR = 9.11 ± 2.6; p = 0.1). The Dixon method led to similar fat suppression (fat SNR with Dixon: 2.1 ± 0.5 vs. SPIR: 2.4 ± 1.2, p = 0.3), but resulted in significantly increased SNR of blood (blood SNR with Dixon: 19.9 ± 4.5 vs. SPIR: 15.5 ± 3.1, p < 0.05). This means the residual fat signal is slightly lower with the Dixon compared to the SIPR technique (although not significant), while the SNR of blood is significantly higher with the Dixon technique. Vessel sharpness of the RCA was similar for Dixon and SPIR (57 ± 7 % vs. 56 ± 9 %, p = 0.2), while the RCA visualized vessel length was increased compared to SPIR fat suppression (107 ± 21 vs. 101 ± 21 mm, p < 0.001). For the LAD, vessel sharpness (50 ± 13 % vs. 50 ± 7 %, p = 0.4) and vessel length (92 ± 46 vs. 90 ± 47 mm, p = 0.4) were similar with both techniques. Consequently, the Dixon technique resulted in an improved visual score of the coronary arteries in the water fat separated images of healthy subjects (RCA: 4.6 ± 0.5 vs. 4.1 ± 0.7, p = 0.01, LAD: 4.1 ± 0.7 vs. 3.5 ± 0.8, p = 0.007). Conclusions: Dixon water-fat separation can significantly improve coronary artery image quality without the use of a contrast agent at 3T.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume29
Issue number5
DOIs
StatePublished - Oct 1 2016

Fingerprint

Coronary Angiography
Fats
Water
Coronary Vessels
Signal-To-Noise Ratio
Magnetic Resonance Angiography
Noise
Healthy Volunteers
Contrast Media
Myocardium

Keywords

  • Coronary magnetic resonance angiography
  • Dixon
  • SPIR
  • Vessel length
  • Vessel sharpness

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Coronary MR angiography at 3T : fat suppression versus water-fat separation. / Nezafat, Maryam; Henningsson, Markus; Ripley, David P.; Dedieu, Nathalie; Greil, Gerald; Greenwood, John P.; Börnert, Peter; Plein, Sven; Botnar, René M.

In: Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 29, No. 5, 01.10.2016, p. 733-738.

Research output: Contribution to journal › Article

Nezafat, M, Henningsson, M, Ripley, DP, Dedieu, N, Greil, G, Greenwood, JP, Börnert, P, Plein, S & Botnar, RM 2016, 'Coronary MR angiography at 3T: fat suppression versus water-fat separation', Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 29, no. 5, pp. 733-738. https://doi.org/10.1007/s10334-016-0550-7
Nezafat M, Henningsson M, Ripley DP, Dedieu N, Greil G, Greenwood JP et al. Coronary MR angiography at 3T: fat suppression versus water-fat separation. Magnetic Resonance Materials in Physics, Biology and Medicine. 2016 Oct 1;29(5):733-738. https://doi.org/10.1007/s10334-016-0550-7
Nezafat, Maryam ; Henningsson, Markus ; Ripley, David P. ; Dedieu, Nathalie ; Greil, Gerald ; Greenwood, John P. ; Börnert, Peter ; Plein, Sven ; Botnar, René M. / Coronary MR angiography at 3T : fat suppression versus water-fat separation. In: Magnetic Resonance Materials in Physics, Biology and Medicine. 2016 ; Vol. 29, No. 5. pp. 733-738.
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title = "Coronary MR angiography at 3T: fat suppression versus water-fat separation",
abstract = "Objectives: To compare Dixon water-fat suppression with spectral pre-saturation with inversion recovery (SPIR) at 3T for coronary magnetic resonance angiography (MRA) and to demonstrate the feasibility of fat suppressed coronary MRA at 3T without administration of a contrast agent. Materials and methods: Coronary MRA with Dixon water-fat separation or with SPIR fat suppression was compared on a 3T scanner equipped with a 32-channel cardiac receiver coil. Eight healthy volunteers were examined. Contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), right coronary artery (RCA), and left anterior descending (LAD) coronary artery sharpness and length were measured and statistically compared. Two experienced cardiologists graded the visual image quality of reformatted Dixon and SPIR images (1: poor quality to 5: excellent quality). Results: Coronary MRA images in healthy volunteers showed improved contrast with the Dixon technique compared to SPIR (CNR blood-fat: Dixon{\^A} ={\^A} 14.9{\^A} {\^A}±{\^A} 2.9 and SPIR{\^A} ={\^A} 13.9{\^A} {\^A}±{\^A} 2.1; p{\^A} ={\^A} 0.08, CNR blood-myocardium: Dixon{\^A} ={\^A} 10.2{\^A} {\^A}±{\^A} 2.7 and SPIR{\^A} ={\^A} 9.11{\^A} {\^A}±{\^A} 2.6; p{\^A} ={\^A} 0.1). The Dixon method led to similar fat suppression (fat SNR with Dixon: 2.1{\^A} {\^A}±{\^A} 0.5 vs. SPIR: 2.4{\^A} {\^A}±{\^A} 1.2, p{\^A} ={\^A} 0.3), but resulted in significantly increased SNR of blood (blood SNR with Dixon: 19.9{\^A} {\^A}±{\^A} 4.5 vs. SPIR: 15.5{\^A} {\^A}±{\^A} 3.1, p{\^A} <{\^A} 0.05). This means the residual fat signal is slightly lower with the Dixon compared to the SIPR technique (although not significant), while the SNR of blood is significantly higher with the Dixon technique. Vessel sharpness of the RCA was similar for Dixon and SPIR (57{\^A} {\^A}±{\^A} 7{\^A} {\%} vs. 56{\^A} {\^A}±{\^A} 9{\^A} {\%}, p{\^A} ={\^A} 0.2), while the RCA visualized vessel length was increased compared to SPIR fat suppression (107{\^A} {\^A}±{\^A} 21 vs. 101{\^A} {\^A}±{\^A} 21{\^A} mm, p{\^A} <{\^A} 0.001). For the LAD, vessel sharpness (50{\^A} {\^A}±{\^A} 13{\^A} {\%} vs. 50{\^A} {\^A}±{\^A} 7{\^A} {\%}, p{\^A} ={\^A} 0.4) and vessel length (92{\^A} {\^A}±{\^A} 46 vs. 90{\^A} {\^A}±{\^A} 47{\^A} mm, p{\^A} ={\^A} 0.4) were similar with both techniques. Consequently, the Dixon technique resulted in an improved visual score of the coronary arteries in the water fat separated images of healthy subjects (RCA: 4.6{\^A} {\^A}±{\^A} 0.5 vs. 4.1{\^A} {\^A}±{\^A} 0.7, p{\^A} ={\^A} 0.01, LAD: 4.1{\^A} {\^A}±{\^A} 0.7 vs. 3.5{\^A} {\^A}±{\^A} 0.8, p{\^A} ={\^A} 0.007). Conclusions: Dixon water-fat separation can significantly improve coronary artery image quality without the use of a contrast agent at 3T.",
keywords = "Coronary magnetic resonance angiography, Dixon, SPIR, Vessel length, Vessel sharpness",
author = "Maryam Nezafat and Markus Henningsson and Ripley, {David P.} and Nathalie Dedieu and Gerald Greil and Greenwood, {John P.} and Peter B{\~A}¶rnert and Sven Plein and Botnar, {Ren{\~A}{\circledC} M.}",
year = "2016",
month = "10",
day = "1",
doi = "10.1007/s10334-016-0550-7",
language = "English (US)",
volume = "29",
pages = "733--738",
journal = "Magnetic Resonance Materials in Physics, Biology, and Medicine",
issn = "1352-8661",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Coronary MR angiography at 3T

T2 - fat suppression versus water-fat separation

AU - Nezafat, Maryam

AU - Henningsson, Markus

AU - Ripley, David P.

AU - Dedieu, Nathalie

AU - Greil, Gerald

AU - Greenwood, John P.

AU - Börnert, Peter

AU - Plein, Sven

AU - Botnar, René M.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objectives: To compare Dixon water-fat suppression with spectral pre-saturation with inversion recovery (SPIR) at 3T for coronary magnetic resonance angiography (MRA) and to demonstrate the feasibility of fat suppressed coronary MRA at 3T without administration of a contrast agent. Materials and methods: Coronary MRA with Dixon water-fat separation or with SPIR fat suppression was compared on a 3T scanner equipped with a 32-channel cardiac receiver coil. Eight healthy volunteers were examined. Contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), right coronary artery (RCA), and left anterior descending (LAD) coronary artery sharpness and length were measured and statistically compared. Two experienced cardiologists graded the visual image quality of reformatted Dixon and SPIR images (1: poor quality to 5: excellent quality). Results: Coronary MRA images in healthy volunteers showed improved contrast with the Dixon technique compared to SPIR (CNR blood-fat: Dixon = 14.9 ± 2.9 and SPIR = 13.9 ± 2.1; p = 0.08, CNR blood-myocardium: Dixon = 10.2 ± 2.7 and SPIR = 9.11 ± 2.6; p = 0.1). The Dixon method led to similar fat suppression (fat SNR with Dixon: 2.1 ± 0.5 vs. SPIR: 2.4 ± 1.2, p = 0.3), but resulted in significantly increased SNR of blood (blood SNR with Dixon: 19.9 ± 4.5 vs. SPIR: 15.5 ± 3.1, p < 0.05). This means the residual fat signal is slightly lower with the Dixon compared to the SIPR technique (although not significant), while the SNR of blood is significantly higher with the Dixon technique. Vessel sharpness of the RCA was similar for Dixon and SPIR (57 ± 7 % vs. 56 ± 9 %, p = 0.2), while the RCA visualized vessel length was increased compared to SPIR fat suppression (107 ± 21 vs. 101 ± 21 mm, p < 0.001). For the LAD, vessel sharpness (50 ± 13 % vs. 50 ± 7 %, p = 0.4) and vessel length (92 ± 46 vs. 90 ± 47 mm, p = 0.4) were similar with both techniques. Consequently, the Dixon technique resulted in an improved visual score of the coronary arteries in the water fat separated images of healthy subjects (RCA: 4.6 ± 0.5 vs. 4.1 ± 0.7, p = 0.01, LAD: 4.1 ± 0.7 vs. 3.5 ± 0.8, p = 0.007). Conclusions: Dixon water-fat separation can significantly improve coronary artery image quality without the use of a contrast agent at 3T.

AB - Objectives: To compare Dixon water-fat suppression with spectral pre-saturation with inversion recovery (SPIR) at 3T for coronary magnetic resonance angiography (MRA) and to demonstrate the feasibility of fat suppressed coronary MRA at 3T without administration of a contrast agent. Materials and methods: Coronary MRA with Dixon water-fat separation or with SPIR fat suppression was compared on a 3T scanner equipped with a 32-channel cardiac receiver coil. Eight healthy volunteers were examined. Contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), right coronary artery (RCA), and left anterior descending (LAD) coronary artery sharpness and length were measured and statistically compared. Two experienced cardiologists graded the visual image quality of reformatted Dixon and SPIR images (1: poor quality to 5: excellent quality). Results: Coronary MRA images in healthy volunteers showed improved contrast with the Dixon technique compared to SPIR (CNR blood-fat: Dixon = 14.9 ± 2.9 and SPIR = 13.9 ± 2.1; p = 0.08, CNR blood-myocardium: Dixon = 10.2 ± 2.7 and SPIR = 9.11 ± 2.6; p = 0.1). The Dixon method led to similar fat suppression (fat SNR with Dixon: 2.1 ± 0.5 vs. SPIR: 2.4 ± 1.2, p = 0.3), but resulted in significantly increased SNR of blood (blood SNR with Dixon: 19.9 ± 4.5 vs. SPIR: 15.5 ± 3.1, p < 0.05). This means the residual fat signal is slightly lower with the Dixon compared to the SIPR technique (although not significant), while the SNR of blood is significantly higher with the Dixon technique. Vessel sharpness of the RCA was similar for Dixon and SPIR (57 ± 7 % vs. 56 ± 9 %, p = 0.2), while the RCA visualized vessel length was increased compared to SPIR fat suppression (107 ± 21 vs. 101 ± 21 mm, p < 0.001). For the LAD, vessel sharpness (50 ± 13 % vs. 50 ± 7 %, p = 0.4) and vessel length (92 ± 46 vs. 90 ± 47 mm, p = 0.4) were similar with both techniques. Consequently, the Dixon technique resulted in an improved visual score of the coronary arteries in the water fat separated images of healthy subjects (RCA: 4.6 ± 0.5 vs. 4.1 ± 0.7, p = 0.01, LAD: 4.1 ± 0.7 vs. 3.5 ± 0.8, p = 0.007). Conclusions: Dixon water-fat separation can significantly improve coronary artery image quality without the use of a contrast agent at 3T.

KW - Coronary magnetic resonance angiography

KW - Dixon

KW - SPIR

KW - Vessel length

KW - Vessel sharpness

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