Coronary vessel wall contrast enhancement imaging as a potential direct marker of coronary involvement: Integration of findings from CAD and SLE patients

Niharika Varma, Rocio Hinojar, David D'Cruz, Eduardo Arroyo Ucar, Andreas Indermuehle, Sarah Peel, Gerald Greil, Nicholas Gaddum, Phil Chowienczyk, Eike Nagel, Rene M. Botnar, Valentina O. Puntmann

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objectives This study investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. Background Coronary CE by cardiac magnetic resonance (CMR) is a novel noninvasive approach to visualize gadolinium contrast uptake within the coronary artery vessel wall. Methods A total of 75 subjects (CAD: n = 25; SLE: n = 27; control: n = 23) underwent CMR imaging using a 3-T clinical scanner. Coronary arteries were visualized by a T2-prepared steady state free precession technique. Coronary wall CE was visualized using inversion-recovery T1 weighted gradient echo sequence 40 min after administration of 0.2 mmol/kg gadobutrol. Proximal coronary segments were visually examined for distribution of CE and quantified for contrast-to-noise ratio (CNR) and total CE area. Results Coronary CE was prevalent in patients (93%, n = 42) with a diffuse pattern for SLE and a patchy/regional distribution in CAD patients. Compared with control subjects, CNR values and total CE area in patients with CAD and SLE were significantly higher (mean CNR: 3.9 ± 2.5 vs. 6.9 ± 2.5 vs. 6.8 ± 2.0, respectively; p < 0.001; total CE area: median 0.8 [interquartile range (IQR): 0.6 to 1.2] vs. 3.2 [IQR: 2.6 to 4.0] vs. 3.3 [IQR: 1.9 to 4.5], respectively; p < 0.001). Both measures were positively associated with aortic stiffness (CNR: r = 0.61, p < 0.01; total CE area: 0.36, p = 0.03), hypercholesterolemia (r = 0.68, p < 0.001; r = 0.61, p < 0.001) and hypertension (r = 0.40, p < 0.01; r = 0.32, p < 0.05). Conclusions We demonstrate that quantification of coronary CE by CNR and total CE area is feasible for detection of subclinical and clinical uptake of gadolinium within the coronary vessel wall. Coronary vessel wall CE may become an instrumental novel direct marker of vessel wall injury and remodeling in subpopulations at risk.

Original languageEnglish (US)
Pages (from-to)762-770
Number of pages9
JournalJACC: Cardiovascular Imaging
Volume7
Issue number8
DOIs
StatePublished - Jan 1 2014

Fingerprint

Systemic Lupus Erythematosus
Coronary Artery Disease
Coronary Vessels
Noise
Vascular Stiffness
Gadolinium
Feasibility Studies
Vasculitis
Hypercholesterolemia
Autoimmune Diseases
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Hypertension
Wounds and Injuries

Keywords

  • cardiac magnetic resonance
  • contrast-to-noise ratio
  • coronary enhancement
  • vessel wall remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Coronary vessel wall contrast enhancement imaging as a potential direct marker of coronary involvement : Integration of findings from CAD and SLE patients. / Varma, Niharika; Hinojar, Rocio; D'Cruz, David; Arroyo Ucar, Eduardo; Indermuehle, Andreas; Peel, Sarah; Greil, Gerald; Gaddum, Nicholas; Chowienczyk, Phil; Nagel, Eike; Botnar, Rene M.; Puntmann, Valentina O.

In: JACC: Cardiovascular Imaging, Vol. 7, No. 8, 01.01.2014, p. 762-770.

Research output: Contribution to journalArticle

Varma, N, Hinojar, R, D'Cruz, D, Arroyo Ucar, E, Indermuehle, A, Peel, S, Greil, G, Gaddum, N, Chowienczyk, P, Nagel, E, Botnar, RM & Puntmann, VO 2014, 'Coronary vessel wall contrast enhancement imaging as a potential direct marker of coronary involvement: Integration of findings from CAD and SLE patients', JACC: Cardiovascular Imaging, vol. 7, no. 8, pp. 762-770. https://doi.org/10.1016/j.jcmg.2014.03.012
Varma, Niharika ; Hinojar, Rocio ; D'Cruz, David ; Arroyo Ucar, Eduardo ; Indermuehle, Andreas ; Peel, Sarah ; Greil, Gerald ; Gaddum, Nicholas ; Chowienczyk, Phil ; Nagel, Eike ; Botnar, Rene M. ; Puntmann, Valentina O. / Coronary vessel wall contrast enhancement imaging as a potential direct marker of coronary involvement : Integration of findings from CAD and SLE patients. In: JACC: Cardiovascular Imaging. 2014 ; Vol. 7, No. 8. pp. 762-770.
@article{67284e1c4c6c4ef4b7943670ff38ddfd,
title = "Coronary vessel wall contrast enhancement imaging as a potential direct marker of coronary involvement: Integration of findings from CAD and SLE patients",
abstract = "Objectives This study investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. Background Coronary CE by cardiac magnetic resonance (CMR) is a novel noninvasive approach to visualize gadolinium contrast uptake within the coronary artery vessel wall. Methods A total of 75 subjects (CAD: n = 25; SLE: n = 27; control: n = 23) underwent CMR imaging using a 3-T clinical scanner. Coronary arteries were visualized by a T2-prepared steady state free precession technique. Coronary wall CE was visualized using inversion-recovery T1 weighted gradient echo sequence 40 min after administration of 0.2 mmol/kg gadobutrol. Proximal coronary segments were visually examined for distribution of CE and quantified for contrast-to-noise ratio (CNR) and total CE area. Results Coronary CE was prevalent in patients (93{\%}, n = 42) with a diffuse pattern for SLE and a patchy/regional distribution in CAD patients. Compared with control subjects, CNR values and total CE area in patients with CAD and SLE were significantly higher (mean CNR: 3.9 ± 2.5 vs. 6.9 ± 2.5 vs. 6.8 ± 2.0, respectively; p < 0.001; total CE area: median 0.8 [interquartile range (IQR): 0.6 to 1.2] vs. 3.2 [IQR: 2.6 to 4.0] vs. 3.3 [IQR: 1.9 to 4.5], respectively; p < 0.001). Both measures were positively associated with aortic stiffness (CNR: r = 0.61, p < 0.01; total CE area: 0.36, p = 0.03), hypercholesterolemia (r = 0.68, p < 0.001; r = 0.61, p < 0.001) and hypertension (r = 0.40, p < 0.01; r = 0.32, p < 0.05). Conclusions We demonstrate that quantification of coronary CE by CNR and total CE area is feasible for detection of subclinical and clinical uptake of gadolinium within the coronary vessel wall. Coronary vessel wall CE may become an instrumental novel direct marker of vessel wall injury and remodeling in subpopulations at risk.",
keywords = "cardiac magnetic resonance, contrast-to-noise ratio, coronary enhancement, vessel wall remodeling",
author = "Niharika Varma and Rocio Hinojar and David D'Cruz and {Arroyo Ucar}, Eduardo and Andreas Indermuehle and Sarah Peel and Gerald Greil and Nicholas Gaddum and Phil Chowienczyk and Eike Nagel and Botnar, {Rene M.} and Puntmann, {Valentina O.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.jcmg.2014.03.012",
language = "English (US)",
volume = "7",
pages = "762--770",
journal = "JACC: Cardiovascular Imaging",
issn = "1936-878X",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Coronary vessel wall contrast enhancement imaging as a potential direct marker of coronary involvement

T2 - Integration of findings from CAD and SLE patients

AU - Varma, Niharika

AU - Hinojar, Rocio

AU - D'Cruz, David

AU - Arroyo Ucar, Eduardo

AU - Indermuehle, Andreas

AU - Peel, Sarah

AU - Greil, Gerald

AU - Gaddum, Nicholas

AU - Chowienczyk, Phil

AU - Nagel, Eike

AU - Botnar, Rene M.

AU - Puntmann, Valentina O.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objectives This study investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. Background Coronary CE by cardiac magnetic resonance (CMR) is a novel noninvasive approach to visualize gadolinium contrast uptake within the coronary artery vessel wall. Methods A total of 75 subjects (CAD: n = 25; SLE: n = 27; control: n = 23) underwent CMR imaging using a 3-T clinical scanner. Coronary arteries were visualized by a T2-prepared steady state free precession technique. Coronary wall CE was visualized using inversion-recovery T1 weighted gradient echo sequence 40 min after administration of 0.2 mmol/kg gadobutrol. Proximal coronary segments were visually examined for distribution of CE and quantified for contrast-to-noise ratio (CNR) and total CE area. Results Coronary CE was prevalent in patients (93%, n = 42) with a diffuse pattern for SLE and a patchy/regional distribution in CAD patients. Compared with control subjects, CNR values and total CE area in patients with CAD and SLE were significantly higher (mean CNR: 3.9 ± 2.5 vs. 6.9 ± 2.5 vs. 6.8 ± 2.0, respectively; p < 0.001; total CE area: median 0.8 [interquartile range (IQR): 0.6 to 1.2] vs. 3.2 [IQR: 2.6 to 4.0] vs. 3.3 [IQR: 1.9 to 4.5], respectively; p < 0.001). Both measures were positively associated with aortic stiffness (CNR: r = 0.61, p < 0.01; total CE area: 0.36, p = 0.03), hypercholesterolemia (r = 0.68, p < 0.001; r = 0.61, p < 0.001) and hypertension (r = 0.40, p < 0.01; r = 0.32, p < 0.05). Conclusions We demonstrate that quantification of coronary CE by CNR and total CE area is feasible for detection of subclinical and clinical uptake of gadolinium within the coronary vessel wall. Coronary vessel wall CE may become an instrumental novel direct marker of vessel wall injury and remodeling in subpopulations at risk.

AB - Objectives This study investigated the feasibility of visual and quantitative assessment of coronary vessel wall contrast enhancement (CE) for detection of symptomatic atherosclerotic coronary artery disease (CAD) and subclinical coronary vasculitis in autoimmune inflammatory disease (systemic lupus erythematosus [SLE]), as well as the association with aortic stiffness, an established marker of risk. Background Coronary CE by cardiac magnetic resonance (CMR) is a novel noninvasive approach to visualize gadolinium contrast uptake within the coronary artery vessel wall. Methods A total of 75 subjects (CAD: n = 25; SLE: n = 27; control: n = 23) underwent CMR imaging using a 3-T clinical scanner. Coronary arteries were visualized by a T2-prepared steady state free precession technique. Coronary wall CE was visualized using inversion-recovery T1 weighted gradient echo sequence 40 min after administration of 0.2 mmol/kg gadobutrol. Proximal coronary segments were visually examined for distribution of CE and quantified for contrast-to-noise ratio (CNR) and total CE area. Results Coronary CE was prevalent in patients (93%, n = 42) with a diffuse pattern for SLE and a patchy/regional distribution in CAD patients. Compared with control subjects, CNR values and total CE area in patients with CAD and SLE were significantly higher (mean CNR: 3.9 ± 2.5 vs. 6.9 ± 2.5 vs. 6.8 ± 2.0, respectively; p < 0.001; total CE area: median 0.8 [interquartile range (IQR): 0.6 to 1.2] vs. 3.2 [IQR: 2.6 to 4.0] vs. 3.3 [IQR: 1.9 to 4.5], respectively; p < 0.001). Both measures were positively associated with aortic stiffness (CNR: r = 0.61, p < 0.01; total CE area: 0.36, p = 0.03), hypercholesterolemia (r = 0.68, p < 0.001; r = 0.61, p < 0.001) and hypertension (r = 0.40, p < 0.01; r = 0.32, p < 0.05). Conclusions We demonstrate that quantification of coronary CE by CNR and total CE area is feasible for detection of subclinical and clinical uptake of gadolinium within the coronary vessel wall. Coronary vessel wall CE may become an instrumental novel direct marker of vessel wall injury and remodeling in subpopulations at risk.

KW - cardiac magnetic resonance

KW - contrast-to-noise ratio

KW - coronary enhancement

KW - vessel wall remodeling

UR - http://www.scopus.com/inward/record.url?scp=84905985452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905985452&partnerID=8YFLogxK

U2 - 10.1016/j.jcmg.2014.03.012

DO - 10.1016/j.jcmg.2014.03.012

M3 - Article

C2 - 25051945

AN - SCOPUS:84905985452

VL - 7

SP - 762

EP - 770

JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

SN - 1936-878X

IS - 8

ER -