Corpus callosum damage and interhemispheric transfer of information following closed head injury in children

Debra A. Benavidez, Jack M. Fletcher, H. Julia Hannay, Sondra T. Bland, Susan E. Caudle, Dianne B. Mendelsohn, Joel Yeakley, Donald G. Brunder, Harriet Harward, James Song, Nancy A. Perachio, Derek Bruce, Randall S. Scheibel, Matthew A. Lilly, Katia Verger-Maestre, Harvey S. Levin

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We evaluated the relationship of corpus callosum atrophy and/or lesions on magnetic resonance imaging (MRI) to functional hemispheric disconnection following closed head injury (CHI) in 51 pediatric patients, including mild CHI, moderate to severe CHI with extracallosal lesions, and moderate to severe CHI with callosal atrophy and/or lesions. Interhemispheric transfer of information was assessed using auditory, motor, tactile, and visual tests in patients and in 16 uninjured children. Total and regional callosal areas were measured from the midsagittal MRI slice by morphometry. The corpus callosum lesion group demonstrated a greater right ear advantage on verbal dichotic listening than all other groups. Areas of the posterior corpus callosum were negatively correlated with laterality indices of verbal dichotic listening performance and tachistoscopic identification of verbal material. The relationship of corpus callosum atrophy and/or lesions to asymmetry in dichotic listening is consistent with previous investigation of posttraumatic hemispheric disconnection effects in adults.

Original languageEnglish (US)
Pages (from-to)315-336
Number of pages22
JournalCortex
Volume35
Issue number3
Publication statusPublished - Jun 1999

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Keywords

  • Children
  • Closed head injury
  • Corpus callosum
  • Dichotic listening

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Benavidez, D. A., Fletcher, J. M., Hannay, H. J., Bland, S. T., Caudle, S. E., Mendelsohn, D. B., ... Levin, H. S. (1999). Corpus callosum damage and interhemispheric transfer of information following closed head injury in children. Cortex, 35(3), 315-336.