Correction of B0 susceptibility induced distortion in diffusion-weighted images using large-deformation diffeomorphic metric mapping

Hao Huang, Can Ceritoglu, Xin Li, Anqi Qiu, Michael I. Miller, Peter C M van Zijl, Susumu Mori

Research output: Contribution to journalArticle

66 Scopus citations


Geometric distortion caused by B0 inhomogeneity is one of the most important problems for diffusion-weighted images (DWI) using single-shot, echo planar imaging (SS-EPI). In this study, large-deformation, diffeomorphic metric mapping (LDDMM) algorithm has been tested for the correction of geometric distortion in diffusion tensor images (DTI). Based on data from nine normal subjects, the amount of distortion caused by B0 susceptibility in the 3-T magnet was characterized. The distortion quality was validated by manually placing landmarks in the target and DTI images before and after distortion correction. The distortion was found to be up to 15 mm in the population-averaged map and could be more than 20 mm in individual images. Both qualitative demonstration and quantitative statistical results suggest that the highly elastic geometric distortion caused by spatial inhomogeneity of the B0 field in DTI using SS-EPI can be effectively corrected by LDDMM. This postprocessing method is especially useful for correcting existent DTI data without phase maps.

Original languageEnglish (US)
Pages (from-to)1294-1302
Number of pages9
JournalMagnetic Resonance Imaging
Issue number9
StatePublished - Nov 1 2008



  • B0 susceptibility
  • DTI
  • Distortion
  • EPI
  • Registration

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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