Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non-renal Clearable Nanocarriers

Chuanqi Peng, Mengxiao Yu, Jer Tsong Hsieh, Payal Kapur, Jie Zheng

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a head-to-head comparison between 5 nm renal clearable and 30 nm non-renal clearable gold nanoparticle (AuNP)-based drug delivery systems (DDSs) in the delivery of doxorubicin (DOX). While the two DDSs themselves had comparable tumor targeting, we found their different vascular permeability played an even more important role than blood retention in the delivery and intratumoral transport of DOX, of which tumor accumulation, efficacy, and therapeutic index were enhanced 2, 7, and 10-fold, respectively, for the 5 nm DDS over 30 nm one. These findings indicate that ultrahigh vascular permeability of renal clearable nanocarriers can be utilized to further improve anticancer drug delivery without the need for prolonged blood retention.

Original languageEnglish (US)
Pages (from-to)12076-12080
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number35
DOIs
StatePublished - 2019

Keywords

  • drug delivery
  • gold nanoparticles
  • intratumoral transport
  • therapeutic index
  • vascular permeability

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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