Correlating telomerase activity levels with human neuroblastoma outcomes

E. Hiyama, K. Hiyama, T. Yokoyama, Y. Matsuura, M. A. Piatyszek, J. W. Shay

Research output: Contribution to journalArticle

Abstract

Telomerase activity was analysed in 100 neuroblastoma cases. Although telomerase activity was not detected in normal adrenal tissues or benign ganglioneuromas, almost all neuroblastomas (94%) did express it, suggesting an important role for telomerase in neuroblastoma development. Neuroblastomas with high telomerase activity had other genetic changes (for example, N-myc amplification) and an unfavourable prognosis, whereas turnouts with low telomerase activity were devoid of such genetic alterations and were associated with a favourable prognosis. Three neuroblastomas lacking telomerase activity regressed (stage IVS). Thus telomerase expression may be required as a critical step in the multigenetic process of tumorigenesis, and two different pathways may exist for the development of neuroblastoma.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalNature Medicine
Volume1
Issue number3
StatePublished - 1995

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Telomerase
Neuroblastoma
Ganglioneuroma
Amplification
Carcinogenesis
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M. A., & Shay, J. W. (1995). Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Medicine, 1(3), 249-255.

Correlating telomerase activity levels with human neuroblastoma outcomes. / Hiyama, E.; Hiyama, K.; Yokoyama, T.; Matsuura, Y.; Piatyszek, M. A.; Shay, J. W.

In: Nature Medicine, Vol. 1, No. 3, 1995, p. 249-255.

Research output: Contribution to journalArticle

Hiyama, E, Hiyama, K, Yokoyama, T, Matsuura, Y, Piatyszek, MA & Shay, JW 1995, 'Correlating telomerase activity levels with human neuroblastoma outcomes', Nature Medicine, vol. 1, no. 3, pp. 249-255.
Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW. Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Medicine. 1995;1(3):249-255.
Hiyama, E. ; Hiyama, K. ; Yokoyama, T. ; Matsuura, Y. ; Piatyszek, M. A. ; Shay, J. W. / Correlating telomerase activity levels with human neuroblastoma outcomes. In: Nature Medicine. 1995 ; Vol. 1, No. 3. pp. 249-255.
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