Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4

M. A. Catalano, D. A. Carson, P. Stastny, S. Freer, J. H. Vaughan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a micro-immunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P < 10 -4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P = 0.51) or anti-EBNA titers (P = 0.89). We conclude that: 1) most normal adults have RANA antibody by IF; 2) anti-RANA and anti-EBNA titers are closely related; 3) the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

Original languageEnglish (US)
Pages (from-to)1049-1052
Number of pages4
JournalArthritis and Rheumatism
Volume23
Issue number9
DOIs
StatePublished - 1980

Fingerprint

Nuclear Antigens
Antibodies
Isoantigens
Immunodiffusion
Indirect Fluorescent Antibody Technique
Fluorescent Antibody Technique
rheumatoid arthritis nuclear antigen
B-Lymphocytes
Serum

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4. / Catalano, M. A.; Carson, D. A.; Stastny, P.; Freer, S.; Vaughan, J. H.

In: Arthritis and Rheumatism, Vol. 23, No. 9, 1980, p. 1049-1052.

Research output: Contribution to journalArticle

Catalano, M. A. ; Carson, D. A. ; Stastny, P. ; Freer, S. ; Vaughan, J. H. / Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4. In: Arthritis and Rheumatism. 1980 ; Vol. 23, No. 9. pp. 1049-1052.
@article{74c7a0dd33974f79a8e05e3b147d7073,
title = "Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4",
abstract = "We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76{\%} had RANA antibody, compared to 23{\%} by a micro-immunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P < 10 -4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P = 0.51) or anti-EBNA titers (P = 0.89). We conclude that: 1) most normal adults have RANA antibody by IF; 2) anti-RANA and anti-EBNA titers are closely related; 3) the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.",
author = "Catalano, {M. A.} and Carson, {D. A.} and P. Stastny and S. Freer and Vaughan, {J. H.}",
year = "1980",
doi = "10.1002/art.1780230913",
language = "English (US)",
volume = "23",
pages = "1049--1052",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4

AU - Catalano, M. A.

AU - Carson, D. A.

AU - Stastny, P.

AU - Freer, S.

AU - Vaughan, J. H.

PY - 1980

Y1 - 1980

N2 - We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a micro-immunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P < 10 -4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P = 0.51) or anti-EBNA titers (P = 0.89). We conclude that: 1) most normal adults have RANA antibody by IF; 2) anti-RANA and anti-EBNA titers are closely related; 3) the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

AB - We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a micro-immunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P < 10 -4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P = 0.51) or anti-EBNA titers (P = 0.89). We conclude that: 1) most normal adults have RANA antibody by IF; 2) anti-RANA and anti-EBNA titers are closely related; 3) the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

UR - http://www.scopus.com/inward/record.url?scp=0018849864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018849864&partnerID=8YFLogxK

U2 - 10.1002/art.1780230913

DO - 10.1002/art.1780230913

M3 - Article

C2 - 6251856

AN - SCOPUS:0018849864

VL - 23

SP - 1049

EP - 1052

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 9

ER -