CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4

M. A. Catalano; D. A. Carson; P. Stastny

CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4

Translated title of the contribution: Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw 4

M. A. Catalano, D. A. Carson, P. Stastny

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10^-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

Translated title of the contribution	Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw 4
Original language	Portuguese
Pages (from-to)	37-41
Number of pages	5
Journal	Arquivos de Reumatologia e Doencas Osteo-Articulares
Volume	2
Issue number	1
State	Published - Jan 1 1981

ASJC Scopus subject areas

Rheumatology

Cite this

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title = "CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4",

abstract = "We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.",

author = "Catalano, {M. A.} and Carson, {D. A.} and P. Stastny",

year = "1981",

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language = "Portuguese",

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T1 - CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4

AU - Catalano, M. A.

AU - Carson, D. A.

AU - Stastny, P.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

AB - We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

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CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4

Abstract

ASJC Scopus subject areas

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