CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4

Translated title of the contribution: Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw 4

M. A. Catalano, D. A. Carson, P. Stastny

Research output: Contribution to journalArticle

Abstract

We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

Original languageUndefined
Pages (from-to)37-41
Number of pages5
JournalArquivos de Reumatologia e Doencas Osteo-Articulares
Volume2
Issue number1
StatePublished - 1981

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Nuclear Antigens
Antibodies
Isoantigens
Indirect Fluorescent Antibody Technique
Fluorescent Antibody Technique
rheumatoid arthritis nuclear antigen
Anti-Idiotypic Antibodies
B-Lymphocytes
Serum

ASJC Scopus subject areas

  • Rheumatology

Cite this

CORRELACAO ENTRE OS TITULOS DE ANTI-ANAR E DE ANTI-ANEB EM INDIVIDUOS NORMAIS COM E SEM HLA-DRw 4. / Catalano, M. A.; Carson, D. A.; Stastny, P.

In: Arquivos de Reumatologia e Doencas Osteo-Articulares, Vol. 2, No. 1, 1981, p. 37-41.

Research output: Contribution to journalArticle

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abstract = "We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76{\%} had RANA antibody, compared to 23{\%} by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.",
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N2 - We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

AB - We have determined the relationship of antibody titers to the rheumatoid arthritis nuclear antigen (RANA) and of antibody titers to the Epstein-Barr nuclear antigen (EBNA) to each other and to the DRw4 B cell alloantigen in the sera of 34 normal white adults. By a sensitive indirect immunofluorescence (IF) assay, 76% had RANA antibody, compared to 23% by a microimmunodiffusion assay. The correlation coefficient for the tube dilution titers of anti-RANA and anti-EBNA was 0.61 (P<10-4). The 14 DRw4-positive subjects and the 20 DRw4-negative subjects did not differ with respect to anti-RANA titers (P=0.51) or anti-EBNA titers (P=0.89). We conclude that: most normal adults have RANA antibody by IF; anti-RANA and anti-EBNA titers are closely related; the titers of these antibodies cannot be related to the presence of the DRw4 determinant in normal persons.

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