Abstract
A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a second chronic phase. The chromosomal concomitant of the molecular alteration was a deletion of 17p. These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of some cases of CML and are probably responsible for the development of blast crisis in these cases.
Original language | English (US) |
---|---|
Pages (from-to) | 2441-2444 |
Number of pages | 4 |
Journal | Blood |
Volume | 77 |
Issue number | 11 |
State | Published - Jun 1 1991 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology