Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis

A. Foti, H. G. Ahuja, S. L. Allen, P. Koduru, M. W. Schuster, P. Schulman, M. Bar-Eli, M. J. Cline

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a second chronic phase. The chromosomal concomitant of the molecular alteration was a deletion of 17p. These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of some cases of CML and are probably responsible for the development of blast crisis in these cases.

Original languageEnglish (US)
Pages (from-to)2441-2444
Number of pages4
JournalBlood
Volume77
Issue number11
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Foti, A., Ahuja, H. G., Allen, S. L., Koduru, P., Schuster, M. W., Schulman, P., Bar-Eli, M., & Cline, M. J. (1991). Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis. Blood, 77(11), 2441-2444. https://doi.org/10.1182/blood.v77.11.2441.2441