TY - JOUR
T1 - Correlation of Arterial Stiffness With Left Atrial Volume Index and Left Ventricular Mass Index in Young Adults
T2 - Evaluation by Coronary Computed Tomography Angiography
AU - Osawa, Kazuhiro
AU - Nakanishi, Rine
AU - Miyoshi, Toru
AU - Rahmani, Sina
AU - Ceponiene, Indre
AU - Nezarat, Negin
AU - Kanisawa, Mitsuru
AU - Qi, Hong
AU - Jayawardena, Eranthi
AU - Kim, Nicholas
AU - Ito, Hiroshi
AU - Budoff, Matthew J.
N1 - Funding Information:
This study was funded by Fukuda Denshi, Co Ltd. This study was funded by Fukuda Denshi, Co. Ltd. Matthew J. Budoff received research funds from N.I.H. and GE Healthcare. Kazuhiro Osawa was supported in part by research fellowship awards from the Fukuda Foundation for Medical Technology. The authors thank R. Terrazas and S. Hamal for participating in the data collection and management and H. Bakhsheshi, S. Knox, J. Child, N. Hathiramani, M. Kim, M. Sundiam, F. Flores, Y. Morimitsu, and C. Dailing for their excellent technical support. Finally, the authors thank Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac), for editing a draft of this manuscript.
Funding Information:
This study was funded by Fukuda Denshi, Co Ltd.
Funding Information:
This study was funded by Fukuda Denshi, Co., Ltd. Matthew J. Budoff received research funds from N.I.H. and GE Healthcare. Kazuhiro Osawa was supported in part by research fellowship awards from the Fukuda Foundation for Medical Technology. The authors thank R. Terrazas and S. Hamal for participating in the data collection and management and H. Bakhsheshi, S. Knox, J. Child, N. Hathiramani, M. Kim, M. Sundiam, F. Flores, Y. Morimitsu, and C. Dailing for their excellent technical support. Finally, the authors thank Angela Morben, DVM, ELS, from Edanz Group ( www.edanzediting.com/ac ), for editing a draft of this manuscript.
Publisher Copyright:
© 2018 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS)and the Cardiac Society of Australia and New Zealand (CSANZ)
PY - 2019/6
Y1 - 2019/6
N2 - Background: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. Methods: In total, 73 patients (44 (60%)men)aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI)were measured using coronary computed tomography angiography (CCTA). Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI). An abnormally high CAVI was defined as that above the age- and sex-specific cut-off points of the CAVI. Results: Compared with patients with a normal CAVI, those with an abnormally high CAVI were older and had a greater prevalence of diabetes mellitus, higher diastolic blood pressure, greater coronary artery calcification score, and a greater LAVI (33.5 ± 10.3 vs. 43.0 ± 10.3 mL/m 2 , p < 0.01). In contrast, there were no significant differences in the LVVI or LVMI between the subgroups with a normal CAVI and an abnormally high CAVI. Multivariate linear regression analysis showed that the LAVI was significantly associated with an abnormally high CAVI (standardised regression coefficient = 0.283, p = 0.03). Conclusions: The present study demonstrated that increased arterial stiffness is associated with the LAVI, which reflects the early stages of cardiac remodelling, independent of various comorbidity factors in young adults with suspected coronary artery disease.
AB - Background: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. Methods: In total, 73 patients (44 (60%)men)aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI)were measured using coronary computed tomography angiography (CCTA). Arterial stiffness was assessed with the cardio-ankle vascular index (CAVI). An abnormally high CAVI was defined as that above the age- and sex-specific cut-off points of the CAVI. Results: Compared with patients with a normal CAVI, those with an abnormally high CAVI were older and had a greater prevalence of diabetes mellitus, higher diastolic blood pressure, greater coronary artery calcification score, and a greater LAVI (33.5 ± 10.3 vs. 43.0 ± 10.3 mL/m 2 , p < 0.01). In contrast, there were no significant differences in the LVVI or LVMI between the subgroups with a normal CAVI and an abnormally high CAVI. Multivariate linear regression analysis showed that the LAVI was significantly associated with an abnormally high CAVI (standardised regression coefficient = 0.283, p = 0.03). Conclusions: The present study demonstrated that increased arterial stiffness is associated with the LAVI, which reflects the early stages of cardiac remodelling, independent of various comorbidity factors in young adults with suspected coronary artery disease.
KW - Cardio-ankle vascular index (CAVI)
KW - Coronary computed tomography angiography (CCTA)
KW - Left atrial volume index (LAVI)
KW - Left ventricular mass index (LVMI)
KW - Left ventricular volume index (LVVI)
UR - http://www.scopus.com/inward/record.url?scp=85046671360&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046671360&partnerID=8YFLogxK
U2 - 10.1016/j.hlc.2018.04.286
DO - 10.1016/j.hlc.2018.04.286
M3 - Article
C2 - 29753654
AN - SCOPUS:85046671360
SN - 1443-9506
VL - 28
SP - 932
EP - 938
JO - Heart Lung and Circulation
JF - Heart Lung and Circulation
IS - 6
ER -