Correlation of cone biopsy with findings at radical hysterectomy and use of adjuvant radiation therapy

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4 Scopus citations

Abstract

Objective: To determine if pathologic findings in cone biopsy specimens correlate with residual invasive disease in radical hysterectomy specimens and the need for adjuvant chemo-radiation therapy. Study design: We identified 65 patients who underwent a cone biopsy and subsequent radical hysterectomy. Clinico-pathologic parameters in the cone specimens were correlated with the presence of residual invasive disease in the radical hysterectomy specimens and the need for adjuvant chemo-radiation. Results: A positive endocervical margin, a positive deep margin, a positive post-cone ECC, and positive LVSI were significantly associated with the presence of residual disease in the radical hysterectomy specimen, while positive LVSI, a positive ECC, a positive deep cone margin, and greater than 1 positive margin were significantly associated with the use of adjuvant chemo-radiation therapy. Conclusion: Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation.

Original languageEnglish (US)
Pages (from-to)508-511
Number of pages4
JournalGynecologic Oncology
Volume124
Issue number3
DOIs
Publication statusPublished - Mar 2012

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Keywords

  • Adjuvant chemo-radiation
  • Cervical cancer
  • Cone biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

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