Correlation of cone biopsy with findings at radical hysterectomy and use of adjuvant radiation therapy

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4 Citations (Scopus)

Abstract

Objective: To determine if pathologic findings in cone biopsy specimens correlate with residual invasive disease in radical hysterectomy specimens and the need for adjuvant chemo-radiation therapy. Study design: We identified 65 patients who underwent a cone biopsy and subsequent radical hysterectomy. Clinico-pathologic parameters in the cone specimens were correlated with the presence of residual invasive disease in the radical hysterectomy specimens and the need for adjuvant chemo-radiation. Results: A positive endocervical margin, a positive deep margin, a positive post-cone ECC, and positive LVSI were significantly associated with the presence of residual disease in the radical hysterectomy specimen, while positive LVSI, a positive ECC, a positive deep cone margin, and greater than 1 positive margin were significantly associated with the use of adjuvant chemo-radiation therapy. Conclusion: Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation.

Original languageEnglish (US)
Pages (from-to)508-511
Number of pages4
JournalGynecologic Oncology
Volume124
Issue number3
DOIs
StatePublished - Mar 2012

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Hysterectomy
Radiotherapy
Biopsy
Radiation

Keywords

  • Adjuvant chemo-radiation
  • Cervical cancer
  • Cone biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

@article{0da19ae085304cdabadee2ad3de38467,
title = "Correlation of cone biopsy with findings at radical hysterectomy and use of adjuvant radiation therapy",
abstract = "Objective: To determine if pathologic findings in cone biopsy specimens correlate with residual invasive disease in radical hysterectomy specimens and the need for adjuvant chemo-radiation therapy. Study design: We identified 65 patients who underwent a cone biopsy and subsequent radical hysterectomy. Clinico-pathologic parameters in the cone specimens were correlated with the presence of residual invasive disease in the radical hysterectomy specimens and the need for adjuvant chemo-radiation. Results: A positive endocervical margin, a positive deep margin, a positive post-cone ECC, and positive LVSI were significantly associated with the presence of residual disease in the radical hysterectomy specimen, while positive LVSI, a positive ECC, a positive deep cone margin, and greater than 1 positive margin were significantly associated with the use of adjuvant chemo-radiation therapy. Conclusion: Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation.",
keywords = "Adjuvant chemo-radiation, Cervical cancer, Cone biopsy",
author = "Boren, {Todd P.} and Kelley Carrick and Kehoe, {Siobhan M.} and Jayanthia Lea and Miller, {David S.} and Richardson, {Debra L.}",
year = "2012",
month = "3",
doi = "10.1016/j.ygyno.2011.11.014",
language = "English (US)",
volume = "124",
pages = "508--511",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Correlation of cone biopsy with findings at radical hysterectomy and use of adjuvant radiation therapy

AU - Boren, Todd P.

AU - Carrick, Kelley

AU - Kehoe, Siobhan M.

AU - Lea, Jayanthia

AU - Miller, David S.

AU - Richardson, Debra L.

PY - 2012/3

Y1 - 2012/3

N2 - Objective: To determine if pathologic findings in cone biopsy specimens correlate with residual invasive disease in radical hysterectomy specimens and the need for adjuvant chemo-radiation therapy. Study design: We identified 65 patients who underwent a cone biopsy and subsequent radical hysterectomy. Clinico-pathologic parameters in the cone specimens were correlated with the presence of residual invasive disease in the radical hysterectomy specimens and the need for adjuvant chemo-radiation. Results: A positive endocervical margin, a positive deep margin, a positive post-cone ECC, and positive LVSI were significantly associated with the presence of residual disease in the radical hysterectomy specimen, while positive LVSI, a positive ECC, a positive deep cone margin, and greater than 1 positive margin were significantly associated with the use of adjuvant chemo-radiation therapy. Conclusion: Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation.

AB - Objective: To determine if pathologic findings in cone biopsy specimens correlate with residual invasive disease in radical hysterectomy specimens and the need for adjuvant chemo-radiation therapy. Study design: We identified 65 patients who underwent a cone biopsy and subsequent radical hysterectomy. Clinico-pathologic parameters in the cone specimens were correlated with the presence of residual invasive disease in the radical hysterectomy specimens and the need for adjuvant chemo-radiation. Results: A positive endocervical margin, a positive deep margin, a positive post-cone ECC, and positive LVSI were significantly associated with the presence of residual disease in the radical hysterectomy specimen, while positive LVSI, a positive ECC, a positive deep cone margin, and greater than 1 positive margin were significantly associated with the use of adjuvant chemo-radiation therapy. Conclusion: Pathologic parameters in cone biopsy specimens can estimate the risk of residual invasive disease in radical hysterectomy specimens and the use of adjuvant chemo-radiation.

KW - Adjuvant chemo-radiation

KW - Cervical cancer

KW - Cone biopsy

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U2 - 10.1016/j.ygyno.2011.11.014

DO - 10.1016/j.ygyno.2011.11.014

M3 - Article

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VL - 124

SP - 508

EP - 511

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -