Correlation of serum cholylglycine level with hepatic dysfunction in children with sickle cell anemia

Alain E. Sayad, Roula A. Farah, Zora R. Rogers, James E. Heubi, George R. Buchanan, Robert H. Squires

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hepatic dysfunction occurs commonly in children with sickle cell disease (SCD). Although the etiology is multifactorial, cholestasis is a prominent feature. Serum cholylglycine (CG) has been found to be a very sensitive indicator of cholestasis. Our objective was to determine whether CG levels are elevated in children with SCD and whether they are predictive of hepatic dysfunction. Blood samples were obtained from 97 children with SCD. Liver function tests were done and serum CG concentrations were measured. Patients were followed up for 2 years. Thirty-eight percent of the patients had an elevated CG level. During the 2 years of follow-up, 16% of the children with a previously elevated CG level developed abnormal liver function test results or required a cholecystectomy as compared with 13% with a previously normal CG level (p=0.92). We conclude that although CG level was elevated in 38% of the patients with SCD, it did not appear to predict liver dysfunction during the ensuing 2 years.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalClinical Pediatrics
Volume38
Issue number5
StatePublished - 1999

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Glycocholic Acid
Sickle Cell Anemia
Liver
Serum
Liver Function Tests
Cholestasis
Cholecystectomy
Liver Diseases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Correlation of serum cholylglycine level with hepatic dysfunction in children with sickle cell anemia. / Sayad, Alain E.; Farah, Roula A.; Rogers, Zora R.; Heubi, James E.; Buchanan, George R.; Squires, Robert H.

In: Clinical Pediatrics, Vol. 38, No. 5, 1999, p. 293-296.

Research output: Contribution to journalArticle

Sayad, Alain E. ; Farah, Roula A. ; Rogers, Zora R. ; Heubi, James E. ; Buchanan, George R. ; Squires, Robert H. / Correlation of serum cholylglycine level with hepatic dysfunction in children with sickle cell anemia. In: Clinical Pediatrics. 1999 ; Vol. 38, No. 5. pp. 293-296.
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