Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients

F. Baskin, R. N. Rosenberg, X. Fang, L. S. Hynan, C. B. Moore, M. Weiner, G. L. Vega

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.

Original languageEnglish (US)
Pages (from-to)2006-2007
Number of pages2
JournalNeurology
Volume60
Issue number12
StatePublished - Jun 24 2003

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Amyloid beta-Protein Precursor
Blood Platelets
Lipids
Cholesterol
Neurons
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

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Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. / Baskin, F.; Rosenberg, R. N.; Fang, X.; Hynan, L. S.; Moore, C. B.; Weiner, M.; Vega, G. L.

In: Neurology, Vol. 60, No. 12, 24.06.2003, p. 2006-2007.

Research output: Contribution to journalArticle

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AU - Weiner, M.

AU - Vega, G. L.

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