TY - JOUR
T1 - Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients
AU - Baskin, F.
AU - Rosenberg, R. N.
AU - Fang, X.
AU - Hynan, L. S.
AU - Moore, C. B.
AU - Weiner, M.
AU - Vega, G. L.
PY - 2003/6/24
Y1 - 2003/6/24
N2 - Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.
AB - Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.
UR - http://www.scopus.com/inward/record.url?scp=0038714559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038714559&partnerID=8YFLogxK
U2 - 10.1212/01.WNL.0000068029.56740.96
DO - 10.1212/01.WNL.0000068029.56740.96
M3 - Article
C2 - 12821755
AN - SCOPUS:0038714559
SN - 0028-3878
VL - 60
SP - 2006
EP - 2007
JO - Neurology
JF - Neurology
IS - 12
ER -