Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

Rami R. Hallac, Heling Zhou, Rajesh Pidikiti, Kwang Song, Strahinja Stojadinovic, Dawen Zhao, Timothy Solberg, Peter Peschke, Ralph P. Mason

Research output: Contribution to journalArticle

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Abstract

Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Results Oxygen (100%O2) and carbogen (95%O2/5%CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.

Original languageEnglish (US)
Pages (from-to)1863-1873
Number of pages11
JournalMagnetic Resonance in Medicine
Volume71
Issue number5
DOIs
StatePublished - 2014

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Radiation
Neoplasms
Growth
Oxygen
Respiration
Gases
Oximetry
Prostate

Keywords

  • BOLD
  • carbogen
  • hypoxia
  • MRI
  • oximetry
  • oxygen
  • radiation response

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response. / Hallac, Rami R.; Zhou, Heling; Pidikiti, Rajesh; Song, Kwang; Stojadinovic, Strahinja; Zhao, Dawen; Solberg, Timothy; Peschke, Peter; Mason, Ralph P.

In: Magnetic Resonance in Medicine, Vol. 71, No. 5, 2014, p. 1863-1873.

Research output: Contribution to journalArticle

Hallac, Rami R. ; Zhou, Heling ; Pidikiti, Rajesh ; Song, Kwang ; Stojadinovic, Strahinja ; Zhao, Dawen ; Solberg, Timothy ; Peschke, Peter ; Mason, Ralph P. / Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response. In: Magnetic Resonance in Medicine. 2014 ; Vol. 71, No. 5. pp. 1863-1873.
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abstract = "Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Results Oxygen (100{\%}O2) and carbogen (95{\%}O2/5{\%}CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.",
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N2 - Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Results Oxygen (100%O2) and carbogen (95%O2/5%CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.

AB - Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n = 9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Results Oxygen (100%O2) and carbogen (95%O2/5%CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.

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