Corrigendum to High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype12 (Translational Oncology (2019) 12(2) (256–268), (S193652331830439X), (10.1016/j.tranon.2018.10.010))

N. Golob-Schwarzl, K. Bettermann, A. K. Mehta, S. M. Kessler, J. Unterluggauer, S. Krassnig, K. Kojima, X. Chen, Y. Hoshida, N. M. Bardeesy, H. Müller, V. Svendova, M. G. Schimek, C. Diwoky, A. Lipfert, V. Mahajan, C. Stumptner, A. Thüringer, L. F. Fröhlich, T. StojakovicK. P.R. Nilsson, T. Kolbe, T. Rülicke, T. M. Magin, P. Strnad, A. K. Kiemer, R. Moriggl, Johannes Haybaeck

Research output: Contribution to journalComment/debate

Abstract

The authors regret <insert corrigendum text>. The authors would like to apologize for any inconvenience caused. The authors regret that an error in Figure S1 of the manuscript has been identified. Some images in Figure 1 were duplicated within Figure S1; hence, this corrigendum addresses this error. Following changes were made to improve the quality of the results section: To further address the contribution of KRT8 and KRT18 with respect to liver pathology in livers of wild-type (wt), Krt8+/−, Krt8−/−, Krt18+/ , and Krt18−/− mice aged 3 and 17-20 months, we performed, in addition to light microscopy, double immunofluorescence microscopy (DIF) using antibodies against K8/18 and p62. Moreover, heptameric oligothiophene, h-HTAA (Mahajan et al., 2011), was used to confirm ß-sheet conformation (Figure 1). In livers of 6-month-old Krt18+/− and Krt18−/− mice, total FA amounts were significantly increased compared to wt mice (Figure 2, Figure S1, and Table S1). The following NAFLD-related mRNAs remained largely unchanged: Malonyl-CoA decarboxylase (Mlycd), Microsomal triglyceride transfer protein (Mttp), ATP-binding cassette, sub-family C, member 2 (Cftr/Mrp) (Figure S2A), Insulin receptor substrate 1 (Isr1), Glutamate-cysteine ligase, modifier subunit (Gclm), Fatty acid synthase (Fasn) (Figure S2B), Diacylglycerol O-acyltransferase 2 (Dgat2), Angiotensin II receptor 1a (Agtr1α), Adiponectin receptor 2 (Adipor2) (Figure S2C) and Peroxisome proliferator activated receptor alpha (Pparα) (Figure S2D). In addition, the following changes have been made in the discussion section qRT-PCR analyses revealed a significant increase of Srebpb1 mRNA level in Krt18−/− mice aged 3 and 6 months, whereas no increased mRNA expression of Pparα was identified (Figure 3; Figure S2). [Figure presented] [Figure presented]

Original languageEnglish (US)
Pages (from-to)490-492
Number of pages3
JournalTranslational Oncology
Volume13
Issue number2
DOIs
StatePublished - Feb 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Golob-Schwarzl, N., Bettermann, K., Mehta, A. K., Kessler, S. M., Unterluggauer, J., Krassnig, S., Kojima, K., Chen, X., Hoshida, Y., Bardeesy, N. M., Müller, H., Svendova, V., Schimek, M. G., Diwoky, C., Lipfert, A., Mahajan, V., Stumptner, C., Thüringer, A., Fröhlich, L. F., ... Haybaeck, J. (2020). Corrigendum to High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype12 (Translational Oncology (2019) 12(2) (256–268), (S193652331830439X), (10.1016/j.tranon.2018.10.010)). Translational Oncology, 13(2), 490-492. https://doi.org/10.1016/j.tranon.2019.08.001