Cortical inhibitory and excitatory correlates of depression severity in children and adolescents

Charles P. Lewis, Paul A. Nakonezny, Stephanie H. Ameis, Jennifer L. Vande Voort, Mustafa M. Husain, Graham J. Emslie, Zafiris J. Daskalakis, Paul E. Croarkin

Research output: Contribution to journalArticle

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Abstract

Objectives Neurophysiologic correlates of depression severity potentially have great utility in diagnosis and treatment planning. Transcranial magnetic stimulation (TMS) measures of cortical inhibition and excitability have shown promise as biomarkers in psychiatry, but no prior work has examined correlates of illness severity in pediatric mood disorders. This study sought to examine the relationship between depression severity and TMS measures of cortical inhibition and excitability in children and adolescents. Methods Twenty-four depressed and 22 healthy control youth underwent TMS testing (cortical silent period [CSP], short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children's Depression Rating Scale-Revised (CDRS-R). Results In the overall sample, the following significant negative correlations were observed: CDRS-R and CSP (right hemisphere, ρ=-0.35, p=0.021); QIDS-A17-SR and CSP (left, ρ=-0.33, p=0.031; right, ρ=-0.42, p=0.004); and CDRS-R and SICI-4 (right, ρ=-0.30, p=0.042). Among healthy control participants, additional significant negative correlations were observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and QIDS-A17-SR and bilateral ICF-15. Limitations Small sample, potential developmental/age- and sex-related effects. Conclusions These preliminary results provide evidence for a relationship between depression severity and dysfunction in GABAergic and glutamatergic cortical processes in a pediatric population.

Original languageEnglish (US)
Pages (from-to)566-575
Number of pages10
JournalJournal of Affective Disorders
Volume190
DOIs
StatePublished - Jan 15 2016

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Depression
Transcranial Magnetic Stimulation
Pediatrics
Mood Disorders
Psychiatry
Healthy Volunteers
Biomarkers
Equipment and Supplies

Keywords

  • Child and adolescent depression
  • Cortical inhibition
  • GABA
  • Glutamate
  • Intracortical facilitation
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Cortical inhibitory and excitatory correlates of depression severity in children and adolescents. / Lewis, Charles P.; Nakonezny, Paul A.; Ameis, Stephanie H.; Vande Voort, Jennifer L.; Husain, Mustafa M.; Emslie, Graham J.; Daskalakis, Zafiris J.; Croarkin, Paul E.

In: Journal of Affective Disorders, Vol. 190, 15.01.2016, p. 566-575.

Research output: Contribution to journalArticle

Lewis, Charles P. ; Nakonezny, Paul A. ; Ameis, Stephanie H. ; Vande Voort, Jennifer L. ; Husain, Mustafa M. ; Emslie, Graham J. ; Daskalakis, Zafiris J. ; Croarkin, Paul E. / Cortical inhibitory and excitatory correlates of depression severity in children and adolescents. In: Journal of Affective Disorders. 2016 ; Vol. 190. pp. 566-575.
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abstract = "Objectives Neurophysiologic correlates of depression severity potentially have great utility in diagnosis and treatment planning. Transcranial magnetic stimulation (TMS) measures of cortical inhibition and excitability have shown promise as biomarkers in psychiatry, but no prior work has examined correlates of illness severity in pediatric mood disorders. This study sought to examine the relationship between depression severity and TMS measures of cortical inhibition and excitability in children and adolescents. Methods Twenty-four depressed and 22 healthy control youth underwent TMS testing (cortical silent period [CSP], short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children's Depression Rating Scale-Revised (CDRS-R). Results In the overall sample, the following significant negative correlations were observed: CDRS-R and CSP (right hemisphere, ρ=-0.35, p=0.021); QIDS-A17-SR and CSP (left, ρ=-0.33, p=0.031; right, ρ=-0.42, p=0.004); and CDRS-R and SICI-4 (right, ρ=-0.30, p=0.042). Among healthy control participants, additional significant negative correlations were observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and QIDS-A17-SR and bilateral ICF-15. Limitations Small sample, potential developmental/age- and sex-related effects. Conclusions These preliminary results provide evidence for a relationship between depression severity and dysfunction in GABAergic and glutamatergic cortical processes in a pediatric population.",
keywords = "Child and adolescent depression, Cortical inhibition, GABA, Glutamate, Intracortical facilitation, Transcranial magnetic stimulation",
author = "Lewis, {Charles P.} and Nakonezny, {Paul A.} and Ameis, {Stephanie H.} and {Vande Voort}, {Jennifer L.} and Husain, {Mustafa M.} and Emslie, {Graham J.} and Daskalakis, {Zafiris J.} and Croarkin, {Paul E.}",
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T1 - Cortical inhibitory and excitatory correlates of depression severity in children and adolescents

AU - Lewis, Charles P.

AU - Nakonezny, Paul A.

AU - Ameis, Stephanie H.

AU - Vande Voort, Jennifer L.

AU - Husain, Mustafa M.

AU - Emslie, Graham J.

AU - Daskalakis, Zafiris J.

AU - Croarkin, Paul E.

PY - 2016/1/15

Y1 - 2016/1/15

N2 - Objectives Neurophysiologic correlates of depression severity potentially have great utility in diagnosis and treatment planning. Transcranial magnetic stimulation (TMS) measures of cortical inhibition and excitability have shown promise as biomarkers in psychiatry, but no prior work has examined correlates of illness severity in pediatric mood disorders. This study sought to examine the relationship between depression severity and TMS measures of cortical inhibition and excitability in children and adolescents. Methods Twenty-four depressed and 22 healthy control youth underwent TMS testing (cortical silent period [CSP], short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children's Depression Rating Scale-Revised (CDRS-R). Results In the overall sample, the following significant negative correlations were observed: CDRS-R and CSP (right hemisphere, ρ=-0.35, p=0.021); QIDS-A17-SR and CSP (left, ρ=-0.33, p=0.031; right, ρ=-0.42, p=0.004); and CDRS-R and SICI-4 (right, ρ=-0.30, p=0.042). Among healthy control participants, additional significant negative correlations were observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and QIDS-A17-SR and bilateral ICF-15. Limitations Small sample, potential developmental/age- and sex-related effects. Conclusions These preliminary results provide evidence for a relationship between depression severity and dysfunction in GABAergic and glutamatergic cortical processes in a pediatric population.

AB - Objectives Neurophysiologic correlates of depression severity potentially have great utility in diagnosis and treatment planning. Transcranial magnetic stimulation (TMS) measures of cortical inhibition and excitability have shown promise as biomarkers in psychiatry, but no prior work has examined correlates of illness severity in pediatric mood disorders. This study sought to examine the relationship between depression severity and TMS measures of cortical inhibition and excitability in children and adolescents. Methods Twenty-four depressed and 22 healthy control youth underwent TMS testing (cortical silent period [CSP], short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children's Depression Rating Scale-Revised (CDRS-R). Results In the overall sample, the following significant negative correlations were observed: CDRS-R and CSP (right hemisphere, ρ=-0.35, p=0.021); QIDS-A17-SR and CSP (left, ρ=-0.33, p=0.031; right, ρ=-0.42, p=0.004); and CDRS-R and SICI-4 (right, ρ=-0.30, p=0.042). Among healthy control participants, additional significant negative correlations were observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and QIDS-A17-SR and bilateral ICF-15. Limitations Small sample, potential developmental/age- and sex-related effects. Conclusions These preliminary results provide evidence for a relationship between depression severity and dysfunction in GABAergic and glutamatergic cortical processes in a pediatric population.

KW - Child and adolescent depression

KW - Cortical inhibition

KW - GABA

KW - Glutamate

KW - Intracortical facilitation

KW - Transcranial magnetic stimulation

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JO - Journal of Affective Disorders

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