Cortisol Metabolism and Visceral Obesity: Role of 11β-Hydroxysteroid Dehydrogenase Type I Enzyme and Reduced Co-factor NADPH

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Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11β-hydroxysteroid dehydrogenase (11β-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11β-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.

Original languageEnglish (US)
Pages (from-to)411-418
Number of pages8
JournalEndocrine Research
Issue number4
Publication statusPublished - 2003



  • 11β-HSD
  • Co-factor NADPH
  • Cortisone reductase deficiency
  • G6PDH
  • H6PDH
  • Visceral obesity

ASJC Scopus subject areas

  • Endocrinology

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