COVID-19 and Hypercoagulability: A Review

Asim Kichloo, Kirk Dettloff, Michael Aljadah, Michael Albosta, Shakeel Jamal, Jagmeet Singh, Farah Wani, Akshay Kumar, Srilakshmi Vallabhaneni, Muhammad Zia Khan

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Thrombotic complications of the novel coronavirus (COVID-19) are a concerning aspect of the disease, due to the high incidence in critically ill patients and poor clinical outcomes. COVID-19 predisposes patients to a hypercoagulable state, however, the pathophysiology behind the thrombotic complications seen in this disease is not well understood. Several mechanisms have been proposed and the pathogenesis likely involves a host immune response contributing to vascular endothelial cell injury, inflammation, activation of the coagulation cascade via tissue factor expression, and shutdown of fibrinolysis. Treatments targeting these pathways may need to be considered to improve clinical outcomes and decrease overall mortality due to thrombotic complications. In this review, we will discuss the proposed pathophysiologic mechanisms for thrombotic complications in COVID-19, as well as treatment strategies for these complications based on the current literature available.

Original languageEnglish (US)
JournalClinical and Applied Thrombosis/Hemostasis
Volume26
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • coagulopathy
  • embolism
  • venous thromboembolism

ASJC Scopus subject areas

  • Hematology

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