Abstract
These experiments test whether creatine, a product of muscular contraction, stimulates myofibrillar protein synthesis. It was found that skeletal muscle cells formed both in vitro and in vivo and cardiac muscle cells formed in vivo synthesize myofibrillar proteins faster when supplied creatine in vitro. The rates of synthesis and/or accumulation of three myofibrillar proteins-myosin heavy chain actin, and creatine kinase-were stimulated by creatine. In contrast, the rates of synthesis of total protein and of deoxyribonucleic acid (DNA) and the activities of several nonmyofibrillar enzymes were not altered by creatine. These include lactic dehydrogenase, cathepsin D, acid phosphatase, and beta-acetylglucosaminidase. It is concluded that creatine selectively stimulated the rate of synthesis of contractile proteins in skeletal and cardiac muscle in vitro and may play a role in muscle hypertrophy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-481 |
| Number of pages | 15 |
| Journal | Recent advances in studies on cardiac structure and metabolism |
| Volume | 8 |
| State | Published - 1975 |
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ASJC Scopus subject areas
- Medicine(all)
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Creatine : a possible stimulus skeletal cardiac muscle hypertrophy. / Ingwall, J. S.; Morales, M. F.; Stockdale, F. E.; Wildenthal, K.
In: Recent advances in studies on cardiac structure and metabolism, Vol. 8, 1975, p. 467-481.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Creatine
T2 - a possible stimulus skeletal cardiac muscle hypertrophy.
AU - Ingwall, J. S.
AU - Morales, M. F.
AU - Stockdale, F. E.
AU - Wildenthal, K.
PY - 1975
Y1 - 1975
N2 - These experiments test whether creatine, a product of muscular contraction, stimulates myofibrillar protein synthesis. It was found that skeletal muscle cells formed both in vitro and in vivo and cardiac muscle cells formed in vivo synthesize myofibrillar proteins faster when supplied creatine in vitro. The rates of synthesis and/or accumulation of three myofibrillar proteins-myosin heavy chain actin, and creatine kinase-were stimulated by creatine. In contrast, the rates of synthesis of total protein and of deoxyribonucleic acid (DNA) and the activities of several nonmyofibrillar enzymes were not altered by creatine. These include lactic dehydrogenase, cathepsin D, acid phosphatase, and beta-acetylglucosaminidase. It is concluded that creatine selectively stimulated the rate of synthesis of contractile proteins in skeletal and cardiac muscle in vitro and may play a role in muscle hypertrophy.
AB - These experiments test whether creatine, a product of muscular contraction, stimulates myofibrillar protein synthesis. It was found that skeletal muscle cells formed both in vitro and in vivo and cardiac muscle cells formed in vivo synthesize myofibrillar proteins faster when supplied creatine in vitro. The rates of synthesis and/or accumulation of three myofibrillar proteins-myosin heavy chain actin, and creatine kinase-were stimulated by creatine. In contrast, the rates of synthesis of total protein and of deoxyribonucleic acid (DNA) and the activities of several nonmyofibrillar enzymes were not altered by creatine. These include lactic dehydrogenase, cathepsin D, acid phosphatase, and beta-acetylglucosaminidase. It is concluded that creatine selectively stimulated the rate of synthesis of contractile proteins in skeletal and cardiac muscle in vitro and may play a role in muscle hypertrophy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016645099&partnerID=8YFLogxK
M3 - Article
C2 - 129840
AN - SCOPUS:0016645099
VL - 8
SP - 467
EP - 481
JO - Recent advances in studies on cardiac structure and metabolism
JF - Recent advances in studies on cardiac structure and metabolism
SN - 0363-5872
ER -