cRGD-functionalized polymer micelles for targeted doxorubicin delivery

Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, Jinming Gao

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).

Original languageEnglish (US)
Pages (from-to)6323-6327
Number of pages5
JournalAngewandte Chemie - International Edition
Volume43
Issue number46
DOIs
StatePublished - Nov 26 2004

Fingerprint

Micelles
Doxorubicin
Polymers
Endothelial cells
Integrins
Tumors

Keywords

  • Antitumor agents
  • Bioorganic chemistry
  • Drug delivery
  • Micelles
  • Peptides

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nasongkla, N., Shuai, X., Ai, H., Weinberg, B. D., Pink, J., Boothman, D. A., & Gao, J. (2004). cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angewandte Chemie - International Edition, 43(46), 6323-6327. https://doi.org/10.1002/anie.200460800

cRGD-functionalized polymer micelles for targeted doxorubicin delivery. / Nasongkla, Norased; Shuai, Xintao; Ai, Hua; Weinberg, Brent D.; Pink, John; Boothman, David A.; Gao, Jinming.

In: Angewandte Chemie - International Edition, Vol. 43, No. 46, 26.11.2004, p. 6323-6327.

Research output: Contribution to journalArticle

Nasongkla, N, Shuai, X, Ai, H, Weinberg, BD, Pink, J, Boothman, DA & Gao, J 2004, 'cRGD-functionalized polymer micelles for targeted doxorubicin delivery', Angewandte Chemie - International Edition, vol. 43, no. 46, pp. 6323-6327. https://doi.org/10.1002/anie.200460800
Nasongkla N, Shuai X, Ai H, Weinberg BD, Pink J, Boothman DA et al. cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angewandte Chemie - International Edition. 2004 Nov 26;43(46):6323-6327. https://doi.org/10.1002/anie.200460800
Nasongkla, Norased ; Shuai, Xintao ; Ai, Hua ; Weinberg, Brent D. ; Pink, John ; Boothman, David A. ; Gao, Jinming. / cRGD-functionalized polymer micelles for targeted doxorubicin delivery. In: Angewandte Chemie - International Edition. 2004 ; Vol. 43, No. 46. pp. 6323-6327.
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