cRGD-functionalized polymer micelles for targeted doxorubicin delivery

Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, Jinming Gao

Research output: Contribution to journalArticle

355 Scopus citations


Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).

Original languageEnglish (US)
Pages (from-to)6323-6327
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number46
StatePublished - Nov 26 2004


  • Antitumor agents
  • Bioorganic chemistry
  • Drug delivery
  • Micelles
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Nasongkla, N., Shuai, X., Ai, H., Weinberg, B. D., Pink, J., Boothman, D. A., & Gao, J. (2004). cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angewandte Chemie - International Edition, 43(46), 6323-6327.