CRISPR/Cas9 and TALE: beyond cut and paste

Liping Deng, Ruotong Ren, Jun Wu, Keiichiro Suzuki, Juan Carlos Izpisua Belmote, Guang Hui Liu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalProtein and Cell
Volume6
Issue number3
DOIs
StatePublished - Mar 2015
Externally publishedYes

Keywords

  • CRISPR/Cas9
  • TALE
  • gene expression
  • genome editing
  • transcription regulation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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