CRISPR/Cas9 and TALE: beyond cut and paste

Liping Deng; Ruotong Ren; Jun Wu; Keiichiro Suzuki; Juan Carlos Izpisua Belmote; Guang Hui Liu

doi:10.1007/s13238-015-0137-5

CRISPR/Cas9 and TALE: beyond cut and paste

Liping Deng, Ruotong Ren, Jun Wu, Keiichiro Suzuki, Juan Carlos Izpisua Belmote, Guang Hui Liu

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

Original language	English (US)
Pages (from-to)	157-159
Number of pages	3
Journal	Protein and Cell
Volume	6
Issue number	3
DOIs	https://doi.org/10.1007/s13238-015-0137-5
State	Published - Mar 2015
Externally published	Yes

Keywords

CRISPR/Cas9
TALE
gene expression
genome editing
transcription regulation

ASJC Scopus subject areas

Biotechnology
Biochemistry
Drug Discovery
Cell Biology

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10.1007/s13238-015-0137-5

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title = "CRISPR/Cas9 and TALE: beyond cut and paste",

abstract = "Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.",

keywords = "CRISPR/Cas9, TALE, gene expression, genome editing, transcription regulation",

author = "Liping Deng and Ruotong Ren and Jun Wu and Keiichiro Suzuki and {Izpisua Belmote}, {Juan Carlos} and Liu, {Guang Hui}",

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year = "2015",

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doi = "10.1007/s13238-015-0137-5",

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T2 - beyond cut and paste

AU - Deng, Liping

AU - Ren, Ruotong

AU - Wu, Jun

AU - Suzuki, Keiichiro

AU - Izpisua Belmote, Juan Carlos

AU - Liu, Guang Hui

PY - 2015/3

Y1 - 2015/3

N2 - Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

AB - Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

KW - CRISPR/Cas9

KW - TALE

KW - gene expression

KW - genome editing

KW - transcription regulation

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ER -

CRISPR/Cas9 and TALE: beyond cut and paste

Abstract

Keywords

ASJC Scopus subject areas

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