Most transcription factorsand RNA regulatory proteins encoded by eukaryotic genomes ranging from yeast to humans contain polypeptide domains variously described as intrinsically disordered, prion-like, or of low complexity (LC). These LC domains exist in an unfolded state when DNA and RNA regulatory proteins are studied in biochemical isolation from cells. Upon incubation in the puriﬁed state, many of these LC domains polymerize into homogeneous, labile amyloid-like ﬁbers. Here, we consider several lines of evidence that may favor biologic utility for LC domain polymers.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)