@article{1a417486ec5e4b93bc0bbe57d7b4e4f4,
title = "Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons",
abstract = "Distinct classes of neurons are generated from progenitor cells distributed in characteristic dorsoventral patterns in the developing spinal neural tube. We define restricted neural progenitor populations by the discrete, nonoverlapping expression of Ngn1, Math1, and Mash1. Crossinhibition between these bHLH factors is demonstrated and provides a mechanism for the generation of discrete bHLH expression domains. This precise control of bHLH factor expression is essential for proper neural development since as demonstrated in both loss- and gain-of-function experiments, expression of Math1 or Ngn1 in dorsal progenitor cells determines whether LH2A/B- or dorsal Lim1/2-expressing interneurons will develop. Together, the data suggest that although Math1 and Ngn1 appear to be redundant with respect to neurogenesis, they have distinct functions in specifying neuronal subtype in the dorsal neural tube.",
author = "Katherine Gowan and Helms, {Amy W.} and Hunsaker, {Thomas L.} and Tandi Collisson and Ebert, {Philip J.} and Raanan Odom and Johnson, {Jane E.}",
note = "Funding Information: We gratefully acknowledge Drs. Q. Ma, L. Sommers, and D.J. Anderson for genomic clones of mouse Ngn1, cDNA clones c-Ngn1 and c-Ngn2, and the Ngn1 mutant mice, Dr. H. Zoghbi for the Math1 mutant mice, Dr. F. Guillemot for the Ngn2 mutant mice, Drs. Y. Sun and M. Greenberg for the Ngn1 mutant plasmids, and Drs. K. Lee and T.M. Jessell (LH2A/B), E. Turner (Brn3a), and Developmental Studies Hybridoma Bank (39.4D5, 4F2, and 40.1a) for specific antibodies. The Developmental Studies Hybridoma Bank is maintained by the University of Iowa, Department of Biological Sciences, under contract N01-HD-7-3263 from the NICHD. We also gratefully acknowledge the communication of data prior to publication from Drs. F. Guillemot and H. Zoghbi, critical discussion of the manuscript with Drs. E. Turner, Z. Kaprielian, and K. Lee, and the excellent technical support of Ms. T. Savage and Mr. A. Abney. A.W.H. was supported by NIH training grant #T32GM07062. This work was supported in part by the March of Dimes Foundation, the Muscular Dystrophy Association, and NIH #HD 37832 and #NS32817.",
year = "2001",
month = aug,
day = "2",
doi = "10.1016/S0896-6273(01)00367-1",
language = "English (US)",
volume = "31",
pages = "219--232",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}