Crosstalk between adipose tissue and the heart: An update

Chao Li, Xue Nan Sun, Shangang Zhao, Philipp E. Scherer

Research output: Contribution to journalReview articlepeer-review


It is important to understand how different human organs coordinate and interact with each other. Since obesity and cardiac disease frequently coincide, the crosstalk between adipose tissues and heart has drawn attention. We appreciate that specific peptides/proteins, lipids, nucleic acids, and even organelles shuttle between the adipose tissues and heart. These bioactive components can profoundly affect the metabolism of cells in distal organs, including heart. Importantly, this process can be dysregulated under pathophysiological conditions. This also opens the door to efforts targeting these mediators as potential therapeutic strategies to treat patients who manifest diabetes and cardiovascular disease. Here, we summarize the recent progress toward a better understanding of how the adipose tissues and heart interact with each other.

Original languageEnglish (US)
JournalJournal of Translational Internal Medicine
StateAccepted/In press - 2022


  • adipose tissue
  • cardiovascular disease
  • crosstalk
  • heart
  • obesity

ASJC Scopus subject areas

  • Internal Medicine


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