Crosstalk between perivascular adipose tissue and blood vessels

Srinivas Rajsheker, David Manka, Andra L. Blomkalns, Tapan K. Chatterjee, Lynn L. Stoll, Neal L. Weintraub

Research output: Contribution to journalReview article

124 Scopus citations

Abstract

Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined. Emerging evidence suggests that PVAT regulates vascular function through numerous mechanisms, but evidence to date suggests modulation of three key aspects that are the focus of this review: inflammation, vasoreactivity, and smooth muscle cell proliferation.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume10
Issue number2
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Rajsheker, S., Manka, D., Blomkalns, A. L., Chatterjee, T. K., Stoll, L. L., & Weintraub, N. L. (2010). Crosstalk between perivascular adipose tissue and blood vessels. Current Opinion in Pharmacology, 10(2), 191-196. https://doi.org/10.1016/j.coph.2009.11.005