Crowded little caves: Structure and function of caveolae

Amnon Schlegel, Daniela Volonté, Jeffrey A. Engelman, Ferruccio Galbiati, Pravina Mehta, Xiao Lan Zhang, Philipp E. Scherer, Michael P. Lisanti

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

Caveolae are small vesicular invaginations of the cell membrane. It is within this organelle that cells perform transcytosis, potocytosis and signal transduction. These 'little caves' are composed of a mixture of lipids and proteins unlike those found in the plasma membrane proper. The chief structural proteins of caveolae are caveolins. To date, three caveolins (Cav-1, -2 and -3) with unique tissue distributions have been identified. Caveolins form a scaffold onto which many signalling molecules can assemble, to generate pre-assembled signalling complexes. In addition to concentrating these signal transducers within a distinct region of the plasma membrane, caveolin binding may functionally regulate the activation state of caveolae-associated signalling molecules.

Original languageEnglish (US)
Pages (from-to)457-463
Number of pages7
JournalCellular Signalling
Volume10
Issue number7
DOIs
StatePublished - Jul 1998

Keywords

  • Caveolae
  • Caveolin proteins
  • Cell transformation
  • Oncogenes
  • Signal transduction
  • Tumor suppression

ASJC Scopus subject areas

  • Cell Biology

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