Cryptococcal Meningoencephalitis During Convalescence From Severe COVID-19 Pneumonia

Dharani Rohit Thota, Bappaditya Ray, Mirza Hasan, Kartavya Sharma

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive cryptococcal infection in a previously immunocompetent patient complicating coronavirus disease 2019 (COVID-19) pneumonia has not been described before. In this report, a 76-year-old woman survived a bout of respiratory failure from severe COVID-19 pneumonia, during which she received remdesivir, convalescent plasma, corticosteroids, and tocilizumab. Soon after discharge, she developed acute encephalopathy and multifocal ischemic strokes. CSF and blood cultures were positive for Cryptococcus neoformans. Cryptococcal meningoencephalitis should be considered in the differential diagnosis of encephalopathy in a patient with COVID-19. Treatment with high-dose steroids and tocilizumab may be predisposing factors.

Original languageEnglish (US)
JournalThe Neurohospitalist
DOIs
StateAccepted/In press - 2021

Keywords

  • central nervous system infections
  • COVID-19
  • Cryptococcus
  • ischemic stroke
  • meningoencephalitis
  • tocilizumab

ASJC Scopus subject areas

  • Clinical Neurology

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