Crystal structure of active site mutant of antileukemic L-asparaginase reveals conserved zinc-binding site

Medicine & Life Sciences

• Asparaginase 92%
• Asparagine 72%
• Zinc 65%
• Catalytic Domain 61%
• Binding Sites 52%
• Amidohydrolases 32%
• Glutamine 30%
• glutamin-(asparagin-)ase 21%
• Cations 19%
• Precursor Cell Lymphoblastic Leukemia-Lymphoma 19%
• polyethylene glycol-glutaminase-asparaginase 19%
• RNA, Transfer, Asn 18%
• Bacterial Structures 13%
• Escherichia coli 13%
• Apoptosis Regulatory Proteins 11%
• Ammonia 11%
• Mutation 10%
• Ligases 10%
• Transfer RNA 10%
• Mutant Proteins 10%
• Aspartic Acid 10%
• Adenosine Diphosphate 9%
• Therapeutics 9%
• Sequence Analysis 9%
• Metals 8%
• X-Rays 7%
• Proteins 7%
• Observation 6%
• Injections 5%
• Enzymes 5%
• Child 4%
• Pharmaceutical Preparations 4%
• Neoplasms 3%

Chemical Compounds

• Zinc Cation 100%
• Protein Synthesis 70%
• Mutation 57%
• Atomic Coordinate 42%
• Crystal Morphology 34%
• Crystal Structure 33%
• Protein 28%
• Ammonia 25%
• Monoclinic Space Group 25%
• Resistance 21%
• X-Ray 20%
• Drug 17%
• Metal 15%