Cu(OTf) 2 -Catalyzed Beckmann Rearrangement of Ketones Using Hydroxylamine- O -sulfonic Acid (HOSA)

Sailu Munnuri, Saumya Verma, Dinesh Chandra, Raghunath Reddy Anugu, John R. Falck, Jawahar L. Jat

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The Beckmann rearrangement (BKR) of ketones to secondary amides often requires harsh reaction conditions that limit its practicality and scope. Herein, the Cu(OTf) 2 -catalyzed BKR of ketones under mild reaction conditions using hydroxylamine- O -sulfonic acid (HOSA), a commercial water soluble aminating agent, is described. This method is compatible with most functional groups and directly provides the desired amides in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)3709-3714
Number of pages6
JournalSynthesis (Germany)
Volume51
Issue number19
DOIs
StatePublished - 2019

Keywords

  • Beckmann rearrangement
  • Cu(OTf)
  • hydroxylamine- O -sulfonic acid (HOSA)
  • ketone
  • secondary amide

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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