Curcumin, a potential therapeutic candidate for retinal diseases

Lei Lei Wang, Yue Sun, Kun Huang, Ling Zheng

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Curcumin, the major extraction of turmeric, has been widely used in many countries for centuries both as a spice and as a medicine. In the last decade, researchers have found the beneficial effects of curcumin on multiple disorders are due to its antioxidative, anti-inflammatory, and antiproliferative properties, as well as its novel function as an inhibitor of histone aectyltransferases. In this review, we summarize the recent progress made on studying the beneficial effects of curcumin on multiple retinal diseases, including diabetic retinopathy, glaucoma, and age-related macular degeneration. Recent clinical trials on the effectiveness of phosphatidylcholine formulated curcumin in treating eye diseases have also shown promising results, making curcumin a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases.

Original languageEnglish (US)
Pages (from-to)1557-1568
Number of pages12
JournalMolecular Nutrition and Food Research
Volume57
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Anti-inflammation
  • Antioxidative
  • Curcumin
  • Epigenetics
  • Retinal diseases

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

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