Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.
|Original language||English (US)|
|Number of pages||4|
|Journal||The Journal of neuroscience : the official journal of the Society for Neuroscience|
|Publication status||Published - Jul 5 2006|