TY - JOUR
T1 - Current and emerging strategies in the management of Crohn's disease
AU - Randall, Charles
AU - Vizuete, John
AU - Wendorf, Gregg
AU - Ayyar, Balaji
AU - Constantine, Gregory
PY - 2012/10
Y1 - 2012/10
N2 - Diarrhoea is a common manifestation of Crohn's disease (CD). We advocate an evidence-based approach to treat the underlying disease and reduce symptoms. This article reviews disease grading systems, current concepts in medical therapy, and other treatments that may become available in the future. While some drug classes (e.g. salicylates, immunomodulators) have been studied for many decades, newer approaches including anti-TNF monoclonal antibodies (biologics), and gut selective agents are changing the paradigm we use to treat this debilitating condition.
AB - Diarrhoea is a common manifestation of Crohn's disease (CD). We advocate an evidence-based approach to treat the underlying disease and reduce symptoms. This article reviews disease grading systems, current concepts in medical therapy, and other treatments that may become available in the future. While some drug classes (e.g. salicylates, immunomodulators) have been studied for many decades, newer approaches including anti-TNF monoclonal antibodies (biologics), and gut selective agents are changing the paradigm we use to treat this debilitating condition.
KW - Crohn's disease
KW - Diarrhoea
KW - IBD
UR - http://www.scopus.com/inward/record.url?scp=84873341789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873341789&partnerID=8YFLogxK
U2 - 10.1016/j.bpg.2012.11.006
DO - 10.1016/j.bpg.2012.11.006
M3 - Review article
C2 - 23384805
AN - SCOPUS:84873341789
SN - 1521-6918
VL - 26
SP - 601
EP - 610
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
IS - 5
ER -