Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection

Abey Eapen, Ginny L. Ryan, Patrick Ten Eyck, Bradley J. Van Voorhis

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

With increasing use of in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) almost 2% of all babies born in the United States each year are now conceived with these technologies, making outcomes of IVF-ICSI extremely important not only to patients and families but to public health. Twin pregnancy rates after IVF-ICSI in the United States have declined since their peak in 2013 but remain at approximately 1 in 10 to 1 in 20 pregnancies. A review of the current international literature on twin versus singleton pregnancy outcomes after IVF-ICSI treatment confirms statistically significantly higher risks to maternal and perinatal health and statistically significantly higher health care costs. The field of infertility care should continue to work to develop practices that lower twin pregnancy rates to an absolute minimum to maximize the safety of these medical treatments.

Original languageEnglish (US)
Pages (from-to)690-714
Number of pages25
JournalFertility and sterility
Volume114
Issue number4
DOIs
StatePublished - Oct 2020
Externally publishedYes

Keywords

  • Health care costs
  • in vitro fertilization
  • infertility
  • maternal outcomes
  • multiple gestation pregnancy
  • perinatal outcomes
  • twins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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