Current role of MR imaging in the staging of adenocarcinoma of the prostate

Mark L. Schiebler, Mitchell D. Schnall, Howard M. Pollack, Robert E. Lenkinski, John E. Tomaszewski, Alan J. Wein, Richard Whittington, Wolfgang Rauschning, Herbert Y. Kressel

Research output: Contribution to journalArticle

202 Citations (Scopus)

Abstract

Surgical cure of adenocarcinoma of the prostate (ACP) is possible in over 80% of cases when the disease is confined to the gland capsule. The endorectal probe for magnetic resonance (MR) imaging has increased resolution of the prostate gland and capsule, which has improved the sensitivity and specificity for staging ACP (.65 sensitivity, .69 specificity for body coil; .87 sensitivity, .85 specificity for the endorectal coil). Normal glandular regions in the peripheral zone and central zone have significantly higher citrate levels than ACP and fibromuscular and fibrous benign prostatic hyperplasia at proton spectroscopy. ACP has a higher phosphomonoester-phosphocreatine ratio than normal glandular tissue at phosphorus spectroscopy. The combination of endorectal coil MR imaging for local spread, and body coil MR imaging for advanced disease, makes MR imaging the premier imaging modality for the preoperative staging of ACP.

Original languageEnglish (US)
Pages (from-to)339-352
Number of pages14
JournalRadiology
Volume189
Issue number2
StatePublished - Nov 1993

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Prostate
Adenocarcinoma
Magnetic Resonance Imaging
Sensitivity and Specificity
Capsules
Spectrum Analysis
Phosphocreatine
Prostatic Hyperplasia
Citric Acid
Phosphorus
Protons

Keywords

  • Magnetic resonance (MR), spectroscopy
  • Prostate, MR, 844.12141, 844.12145
  • Prostate, neoplasms, 844.324
  • State-of-art reviews

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Schiebler, M. L., Schnall, M. D., Pollack, H. M., Lenkinski, R. E., Tomaszewski, J. E., Wein, A. J., ... Kressel, H. Y. (1993). Current role of MR imaging in the staging of adenocarcinoma of the prostate. Radiology, 189(2), 339-352.

Current role of MR imaging in the staging of adenocarcinoma of the prostate. / Schiebler, Mark L.; Schnall, Mitchell D.; Pollack, Howard M.; Lenkinski, Robert E.; Tomaszewski, John E.; Wein, Alan J.; Whittington, Richard; Rauschning, Wolfgang; Kressel, Herbert Y.

In: Radiology, Vol. 189, No. 2, 11.1993, p. 339-352.

Research output: Contribution to journalArticle

Schiebler, ML, Schnall, MD, Pollack, HM, Lenkinski, RE, Tomaszewski, JE, Wein, AJ, Whittington, R, Rauschning, W & Kressel, HY 1993, 'Current role of MR imaging in the staging of adenocarcinoma of the prostate', Radiology, vol. 189, no. 2, pp. 339-352.
Schiebler ML, Schnall MD, Pollack HM, Lenkinski RE, Tomaszewski JE, Wein AJ et al. Current role of MR imaging in the staging of adenocarcinoma of the prostate. Radiology. 1993 Nov;189(2):339-352.
Schiebler, Mark L. ; Schnall, Mitchell D. ; Pollack, Howard M. ; Lenkinski, Robert E. ; Tomaszewski, John E. ; Wein, Alan J. ; Whittington, Richard ; Rauschning, Wolfgang ; Kressel, Herbert Y. / Current role of MR imaging in the staging of adenocarcinoma of the prostate. In: Radiology. 1993 ; Vol. 189, No. 2. pp. 339-352.
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