Current treatments of primary sclerosing cholangitis

M. Vacca, M. Krawczyk, M. Petruzzelli, R. C. Sasso, K. J. van Erpecum, G. Palasciano, G. P. van Berge-Henegouwen, A. Moschetta, P. Portincasa

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease characterized by hepatic inflammation and obliterative fibrosis, resulting in both intra- and extra-hepatic bile duct strictures. End-stage liver disease and bile duct carcinoma represent frequent complications. Incidence and prevalence of PSC in USA have been recently estimated as 0.9 per 100,000 person-years, and 1.6 per 100,000 person-years, respectively. Major diagnostic criteria include the presence of multifocal strictures, beadings of bile ducts, and compatible biochemical profile, once excluded secondary causes of cholangitis. Since the aetiology of PSC remains poorly defined, medical therapy is currently limited to symptom improvement and prolonged survival. Ursodeoxycholic acid (UDCA), corticosteroids and immunosuppressants have been proposed alone or in combination to improve the clinical outcome. In selected cases, surgical or endoscopic procedures need to be considered. Orthotopic liver transplantation (OLT) is at the moment the only definitive approach although disease relapse has been reported.

Original languageEnglish (US)
Pages (from-to)2081-2094
Number of pages14
JournalCurrent Medicinal Chemistry
Volume14
Issue number19
DOIs
StatePublished - Aug 1 2007

Keywords

  • Biliary obstruction
  • Cholestasis
  • Cirrhosis
  • IBD
  • Immunosuppressant
  • Inflammation
  • Liver
  • UDCA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Vacca, M., Krawczyk, M., Petruzzelli, M., Sasso, R. C., van Erpecum, K. J., Palasciano, G., van Berge-Henegouwen, G. P., Moschetta, A., & Portincasa, P. (2007). Current treatments of primary sclerosing cholangitis. Current Medicinal Chemistry, 14(19), 2081-2094. https://doi.org/10.2174/092986707781368388