Current Understanding of the Genetic Causes of Keloid Formation

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Keloids are an exuberant response to cutaneous wound healing. Several lines of evidence suggest that keloid scarring is influenced by genetic factors. This review will discuss our current understanding of genetic influences on keloidal scarring via familial inheritance patterns; ethnic differences in prevalence; syndromes with keloid occurrence; linkage analysis, genome-wide association studies, and admixture mapping studies; transforming growth factor beta and p53 variant studies; and human leukocyte antigen polymorphisms.

Original languageEnglish (US)
Pages (from-to)S50-S53
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume18
Issue number2
DOIs
StatePublished - Oct 1 2017

Fingerprint

Keloid
Cicatrix
Inheritance Patterns
Genome-Wide Association Study
HLA Antigens
Transforming Growth Factor beta
Wound Healing
Skin

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Current Understanding of the Genetic Causes of Keloid Formation. / Glass, Donald A.

In: Journal of Investigative Dermatology Symposium Proceedings, Vol. 18, No. 2, 01.10.2017, p. S50-S53.

Research output: Contribution to journalReview article

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