Cutaneous features of crouzon syndrome with acanthosis nigricans

Adnan Mir, Timothy Wu, Seth J. Orlow

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Importance: Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described. Observations: We report 6 cases and summarize the existing literature with regard to the cutaneous manifestations of this disorder. All patients have widespread, earlyonset acanthosis nigricans. Patients often have prominent hypopigmented scars at surgical sites and nevi arising early in childhood. Conclusions and Relevance: In addition to craniofacial malformations, Crouzon syndrome with acanthosis nigricans results in characteristic cutaneous findings.

Original languageEnglish (US)
Pages (from-to)737-741
Number of pages5
JournalJAMA Dermatology
Volume149
Issue number6
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Dermatology

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