TY - JOUR
T1 - Cutaneous features of crouzon syndrome with acanthosis nigricans
AU - Mir, Adnan
AU - Wu, Timothy
AU - Orlow, Seth J.
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Importance: Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described. Observations: We report 6 cases and summarize the existing literature with regard to the cutaneous manifestations of this disorder. All patients have widespread, earlyonset acanthosis nigricans. Patients often have prominent hypopigmented scars at surgical sites and nevi arising early in childhood. Conclusions and Relevance: In addition to craniofacial malformations, Crouzon syndrome with acanthosis nigricans results in characteristic cutaneous findings.
AB - Importance: Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described. Observations: We report 6 cases and summarize the existing literature with regard to the cutaneous manifestations of this disorder. All patients have widespread, earlyonset acanthosis nigricans. Patients often have prominent hypopigmented scars at surgical sites and nevi arising early in childhood. Conclusions and Relevance: In addition to craniofacial malformations, Crouzon syndrome with acanthosis nigricans results in characteristic cutaneous findings.
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U2 - 10.1001/jamadermatol.2013.3019
DO - 10.1001/jamadermatol.2013.3019
M3 - Article
C2 - 23571469
AN - SCOPUS:84879394583
VL - 149
SP - 737
EP - 741
JO - Archives of Dermatology
JF - Archives of Dermatology
SN - 2168-6068
IS - 6
ER -