Cutaneous involvement of pre-existing Rosai–Dorfman disease via post-herpetic isotopic response

Neeta Malviya, Alexander Marzuka, Mokhtar Maamed-Tayeb, Lu Le, Travis Vandergriff

Research output: Contribution to journalArticle

Abstract

We report the case of a patient with a long-standing history of extranodal, sinus histiocytosis with massive lymphadenopathy (Rosai–Dorfman disease) and no evidence of original cutaneous involvement as well as a history of herpes zoster of the left flank with post-herpetic neuralgia who went on to develop multiple, round-to-oval, red-brown, atrophic macules and thin papules at the sites of herpes zoster scars on the left flank. Histopathology showed a dense nodular infiltrate of lymphocytes with some plasma cells and numerous large pale-staining histiocytes (S100+/CD68+), consistent with Rosai–Dorfman disease. This case showed exclusively cutaneous involvement, as demonstrated by otherwise normal physical examination, laboratory evaluation and imaging. This is the second reported case of Rosai–Dorfman disease occurring at the site of zoster scars, and to our knowledge this represents the first case report of cutaneous involvement of pre-existing Rosai–Dorfman disease via post-herpetic isotopic response (Wolf's isotopic response).

Original languageEnglish (US)
Pages (from-to)1211-1214
Number of pages4
JournalJournal of Cutaneous Pathology
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • cutaneous
  • isotopic response
  • post-herpetic
  • Rosai–Dorfman
  • zoster

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Fingerprint Dive into the research topics of 'Cutaneous involvement of pre-existing Rosai–Dorfman disease via post-herpetic isotopic response'. Together they form a unique fingerprint.

  • Cite this