Cutaneous squamous cell carcinoma metastasis to the parotid region lymph nodes

Research output: Contribution to journalArticle

Abstract

Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes. Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Uni- and multivariate analyses of disease-specific survival and overall survival were performed. Statistical significance was set at P < 0.05. Results: We evaluated 137 patients. Most patients were Caucasian males with an average age of 71.6 years. The median follow-up time was 29.4 months. Thirty-six percent of patients had pathological evidence of cervical metastasis (N+). Seven percent had metastasis to level I, 21.9% to level II, 14.6% to level III, 8% to level IV, and 9.5% to level V. Thirty-nine percent of patients had metastasis to parotid region (P+). The average number of positive:total nodes from parotidectomy was 1.9:4.6. The median overall and disease-specific survival times were 2.81 and 1.96 years, respectively. Patients with either neck or parotid metastasis (N + or P+) had significantly decreased survival, hazard ratio 2.298 (1.2739, 4.1445), compared to patients without metastasis (N0P0), P < 0.0057. Conclusion: Patients with periauricular region cSCC metastasizing to parotid and cervical regions lymph nodes have significantly decreased survival compared with patients without cervical and/or parotid metastasis. Metastasis to parotid region should be considered as a distinct head and neck level when staging periauricular cancers. This study provides a basis for further studies to validate these findings. Level of Evidence: 4. Laryngoscope, 2018.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StateAccepted/In press - Jan 1 2018

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Parotid Region
Squamous Cell Carcinoma
Lymph Nodes
Neoplasm Metastasis
Skin
Survival
Neck
Laryngoscopes
Neck Dissection
Neoplasm Staging
Multivariate Analysis
Head
Demography

Keywords

  • cutaneous
  • neck
  • neck dissection
  • parotid
  • Skin cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{275daf95d22b4e5b83930d7389668b8d,
title = "Cutaneous squamous cell carcinoma metastasis to the parotid region lymph nodes",
abstract = "Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes. Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Uni- and multivariate analyses of disease-specific survival and overall survival were performed. Statistical significance was set at P < 0.05. Results: We evaluated 137 patients. Most patients were Caucasian males with an average age of 71.6 years. The median follow-up time was 29.4 months. Thirty-six percent of patients had pathological evidence of cervical metastasis (N+). Seven percent had metastasis to level I, 21.9{\%} to level II, 14.6{\%} to level III, 8{\%} to level IV, and 9.5{\%} to level V. Thirty-nine percent of patients had metastasis to parotid region (P+). The average number of positive:total nodes from parotidectomy was 1.9:4.6. The median overall and disease-specific survival times were 2.81 and 1.96 years, respectively. Patients with either neck or parotid metastasis (N + or P+) had significantly decreased survival, hazard ratio 2.298 (1.2739, 4.1445), compared to patients without metastasis (N0P0), P < 0.0057. Conclusion: Patients with periauricular region cSCC metastasizing to parotid and cervical regions lymph nodes have significantly decreased survival compared with patients without cervical and/or parotid metastasis. Metastasis to parotid region should be considered as a distinct head and neck level when staging periauricular cancers. This study provides a basis for further studies to validate these findings. Level of Evidence: 4. Laryngoscope, 2018.",
keywords = "cutaneous, neck, neck dissection, parotid, Skin cancer",
author = "Myers, {Larry L} and Chul Ahn",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/lary.27534",
language = "English (US)",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Cutaneous squamous cell carcinoma metastasis to the parotid region lymph nodes

AU - Myers, Larry L

AU - Ahn, Chul

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes. Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Uni- and multivariate analyses of disease-specific survival and overall survival were performed. Statistical significance was set at P < 0.05. Results: We evaluated 137 patients. Most patients were Caucasian males with an average age of 71.6 years. The median follow-up time was 29.4 months. Thirty-six percent of patients had pathological evidence of cervical metastasis (N+). Seven percent had metastasis to level I, 21.9% to level II, 14.6% to level III, 8% to level IV, and 9.5% to level V. Thirty-nine percent of patients had metastasis to parotid region (P+). The average number of positive:total nodes from parotidectomy was 1.9:4.6. The median overall and disease-specific survival times were 2.81 and 1.96 years, respectively. Patients with either neck or parotid metastasis (N + or P+) had significantly decreased survival, hazard ratio 2.298 (1.2739, 4.1445), compared to patients without metastasis (N0P0), P < 0.0057. Conclusion: Patients with periauricular region cSCC metastasizing to parotid and cervical regions lymph nodes have significantly decreased survival compared with patients without cervical and/or parotid metastasis. Metastasis to parotid region should be considered as a distinct head and neck level when staging periauricular cancers. This study provides a basis for further studies to validate these findings. Level of Evidence: 4. Laryngoscope, 2018.

AB - Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes. Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Uni- and multivariate analyses of disease-specific survival and overall survival were performed. Statistical significance was set at P < 0.05. Results: We evaluated 137 patients. Most patients were Caucasian males with an average age of 71.6 years. The median follow-up time was 29.4 months. Thirty-six percent of patients had pathological evidence of cervical metastasis (N+). Seven percent had metastasis to level I, 21.9% to level II, 14.6% to level III, 8% to level IV, and 9.5% to level V. Thirty-nine percent of patients had metastasis to parotid region (P+). The average number of positive:total nodes from parotidectomy was 1.9:4.6. The median overall and disease-specific survival times were 2.81 and 1.96 years, respectively. Patients with either neck or parotid metastasis (N + or P+) had significantly decreased survival, hazard ratio 2.298 (1.2739, 4.1445), compared to patients without metastasis (N0P0), P < 0.0057. Conclusion: Patients with periauricular region cSCC metastasizing to parotid and cervical regions lymph nodes have significantly decreased survival compared with patients without cervical and/or parotid metastasis. Metastasis to parotid region should be considered as a distinct head and neck level when staging periauricular cancers. This study provides a basis for further studies to validate these findings. Level of Evidence: 4. Laryngoscope, 2018.

KW - cutaneous

KW - neck

KW - neck dissection

KW - parotid

KW - Skin cancer

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U2 - 10.1002/lary.27534

DO - 10.1002/lary.27534

M3 - Article

C2 - 30444261

AN - SCOPUS:85056726984

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

ER -