Abstract
Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-γ production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-γ during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-γ accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-γ production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-γ upon neutrophil activation, the first step during responses to many microbial infections.
Original language | English (US) |
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Pages (from-to) | 36-40 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 195 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2015 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology