Cutting edge: Developmental regulation of IFN-γ production by mouse neutrophil precursor cells

Carolyn R. Sturge, Elise Burger, Megan Raetz, Lora V. Hooper, Felix Yarovinsky

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-γ production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-γ during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-γ accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-γ production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-γ upon neutrophil activation, the first step during responses to many microbial infections.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalJournal of Immunology
Volume195
Issue number1
DOIs
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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