CX3CR1+ macrophages and CD8+ T cells control intestinal IgA production

Young In Kim, Joo Hye Song, Hyun Jeong Ko, Mi Na Kweon, Chang Yuil Kang, Hans Christian Reinecker, Sun Young Chang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Secretory IgA is a key host defense mechanism that controls the intestinal microbiota. We investigated the role of CD11c+CX3CR1+CD64+ macrophages in IgA production in the intestine. Intestinal CX3CR1+ macrophages directly induced IgA secretion by B cells. Ag delivery to lamina propria (LP) CX3CR1+ macrophages specifically induced intestinal IgA production. The induction of IgA by CX3CR1+ macrophages required BAFF, a proliferation-inducing ligand, and TNF-a, but was surprisingly independent of TLR-mediated microbial recognition and retinoic acid signaling. IgA secretion by CX3CR1+ macrophages was enhanced by LP CD8+ T cells through the secretion of IL-9 and IL-13. CX3CR1+ macrophages and CD8+ T cells induced IgA production by B cells independently of mesenteric lymph nodes and Peyer patches. Our data reveal a previously unrecognized cellular circuitry in which LP CX3CR1+ macrophages, B cells, and CD8+ T cells coordinate the protective Ig secretion in the small intestine upon peripheral Ag delivery.

Original languageEnglish (US)
Pages (from-to)1287-1294
Number of pages8
JournalJournal of Immunology
Volume201
Issue number4
DOIs
StatePublished - Aug 15 2018
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kim, Y. I., Song, J. H., Ko, H. J., Kweon, M. N., Kang, C. Y., Reinecker, H. C., & Chang, S. Y. (2018). CX3CR1+ macrophages and CD8+ T cells control intestinal IgA production. Journal of Immunology, 201(4), 1287-1294. https://doi.org/10.4049/jimmunol.1701459