Cyclic adenosine 3'

5'-Monophosphate-binding protein, a biochemical marker of neuroblastoma differentiation

N. Prashad, R. Rosenberg, F. Baskin, D. Sparkman, C. Ulrich, B. Wischmeyer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mouse neuroblastoma tumors show reduced amounts of cyclic adenosine 3':5'-monophosphate (cAMP) binding protein, the level of cAMP-binding protein was increased by 2-fold when the tumor cells were established in tissue culture, and these levels were comparable to that found in mouse brain. This binding protein is a free cAMP-binding protein that is not associated with protein kinase. The reduced amounts of free cAMP-binding protein in tumors are not a consequence of a defective gene, but the synthesis of this protein is regulated at the transcriptional and/or translational levels. The free cAMP-binding protein like the neurotransmitter-synthesizing enzymes can be used as a biochemical marker of differentiation, and this protein may play a role in neuronal differentiation.

Original languageEnglish (US)
JournalCancer Research
Volume40
Issue number8
StatePublished - 1980

Fingerprint

Neuroblastoma
Adenosine
Carrier Proteins
Biomarkers
Neoplasms
Protein Kinases
Neurotransmitter Agents
Proteins
Brain
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cyclic adenosine 3' : 5'-Monophosphate-binding protein, a biochemical marker of neuroblastoma differentiation. / Prashad, N.; Rosenberg, R.; Baskin, F.; Sparkman, D.; Ulrich, C.; Wischmeyer, B.

In: Cancer Research, Vol. 40, No. 8, 1980.

Research output: Contribution to journalArticle

Prashad, N. ; Rosenberg, R. ; Baskin, F. ; Sparkman, D. ; Ulrich, C. ; Wischmeyer, B. / Cyclic adenosine 3' : 5'-Monophosphate-binding protein, a biochemical marker of neuroblastoma differentiation. In: Cancer Research. 1980 ; Vol. 40, No. 8.
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