Cyclic Adenosine 3‘: 5’-Monophosphate-binding Protein, a Biochemical Marker of Neuroblastoma Differentiation

Nagindra Prashad, Roger Rosenberg, Fred Baskin, Dennis Sparkman, Carlene Ulrich, Betsy Wischmeyer

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Mouse neuroblastoma tumors show reduced amounts of cyclic adenosine 3‘:5’-monophosphate (cAMP) binding protein. However, the levels of cAMP-binding protein were increased by 2-fold when the tumor cells were established in tissue culture, and these levels were comparable to that found in mouse brain. This binding protein is a free cAMP-binding protein that is not associated with protein kinase. The reduced amounts of free cAMP-binding protein in tumors are not a consequence of a defective gene, but the synthesis of this protein is regulated at the transcriptional and/or translational levels. The free cAMP-binding protein like the neurotransmitter-synthesizing enzymes can be used as a biochemical marker of differentiation, and this protein may play a role in neuronal differentiation.

Original languageEnglish (US)
Pages (from-to)2884-2889
Number of pages6
JournalCancer Research
Volume40
StatePublished - Aug 1 1980

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Prashad, N., Rosenberg, R., Baskin, F., Sparkman, D., Ulrich, C., & Wischmeyer, B. (1980). Cyclic Adenosine 3‘: 5’-Monophosphate-binding Protein, a Biochemical Marker of Neuroblastoma Differentiation. Cancer Research, 40, 2884-2889.