Cyclocondensation of amino-propargyl silanes

Yizhong Wang, Joseph M. Ready

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Amino-propargyl silanes condense with carbonyl compounds to form imines and subsequently cyclize to form allenylidene tetrahydroquinolines. The cyclocondensations are catalyzed by a variety of Brønsted acids, among which phosphoric acids provide the highest yields. Subsequent intramolecular and intermolecular additions to the allene moiety provide complex polycyclic amines.

Original languageEnglish (US)
Pages (from-to)2308-2311
Number of pages4
JournalOrganic Letters
Volume14
Issue number9
DOIs
StatePublished - May 4 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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