Cyclocondensation of amino-propargyl silanes

Yizhong Wang, Joseph M. Ready

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Amino-propargyl silanes condense with carbonyl compounds to form imines and subsequently cyclize to form allenylidene tetrahydroquinolines. The cyclocondensations are catalyzed by a variety of Brønsted acids, among which phosphoric acids provide the highest yields. Subsequent intramolecular and intermolecular additions to the allene moiety provide complex polycyclic amines.

Original languageEnglish (US)
Pages (from-to)2308-2311
Number of pages4
JournalOrganic Letters
Volume14
Issue number9
DOIs
StatePublished - May 4 2012

Fingerprint

Phosphoric Acids
Silanes
Carbonyl compounds
carbonyl compounds
Imines
phosphoric acid
silanes
imines
Amines
amines
acids
Acids
propadiene
1,2,3,4-tetrahydroquinoline

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Cyclocondensation of amino-propargyl silanes. / Wang, Yizhong; Ready, Joseph M.

In: Organic Letters, Vol. 14, No. 9, 04.05.2012, p. 2308-2311.

Research output: Contribution to journalArticle

Wang, Yizhong ; Ready, Joseph M. / Cyclocondensation of amino-propargyl silanes. In: Organic Letters. 2012 ; Vol. 14, No. 9. pp. 2308-2311.
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